ArticleJournal of cognitive neuroscience2017
Multimodal Imaging Evidence for a Frontoparietal Modulation of Visual Cortex during the Selective Processing of Conditioned Threat.
Article in Journal of cognitive neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Cerebellar Transcranial Alternating Current Stimulation in the Theta Band Prevents Recall of the Initial Fear Association After Extinction Training.Human brain mapping · 2026Trial
- Computerized cognitive training for Chinese mild cognitive impairment patients: A neuropsychological and fMRI study.NeuroImage. Clinical · 2019Trial
- Frontoparietal paired associative stimulation versus single-site stimulation for generalized anxiety disorder: a pilot rTMS study.Journal of psychiatry & neuroscience : JPNTrial
- Distinct Visual Pathways of Threat Retrieval in Fear-Conditioned Faces.Psychophysiology · 2026Article
- Social anxiety is associated with greater autonomic and visuocortical generalization of conditioned aversive responses to faces.Cognitive, affective & behavioral neuroscience · 2026Article
- Applying Bayesian Multilevel Modeling to Single Trial Dynamics: A Demonstration in Aversive Conditioning.Human brain mapping · 2025Article
- Neurophysiological and Autonomic Dynamics of Threat Processing during Sustained Social Fear Generalization.Journal of cognitive neuroscience · 2025Article
- Neural dynamics of attentional resource allocation in early visual cortex: emotional scenes produce competitive interactions.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Neurophysiological and Autonomic Dynamics of Threat Processing During Sustained Social Fear Generalization.bioRxiv : the preprint server for biology · 2024Article
- Threat Expectation Does Not Improve Perceptual Discrimination despite Causing Heightened Priority Processing in the Frontoparietal Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- C-reactive protein moderates associations between racial discrimination and ventromedial prefrontal cortex activation during attention to threat in Black American women.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Sensing fear: fast and precise threat evaluation in human sensory cortex.Trends in cognitive sciences · 2023Review
- Groupwise structural sparsity for discriminative voxels identification.Frontiers in neuroscience · 2023Article
- Attentional capture by angry faces in girls who self-injure: Evidence from steady state visual evoked potentials.Suicide & life-threatening behavior · 2022Article
- Voxel-Mirrored Homotopic Connectivity Is Altered in Meibomian Gland Dysfunction Patients That Are Morbidly Obese.Brain sciences · 2022Article
- Effects of left and right medial temporal lobe resections on hemodynamic correlates of negative and neutral scene processing.Human brain mapping · 2022Article
- Aversive Conditioning of Spatial Position Sharpens Neural Population-Level Tuning in Visual Cortex and Selectively Alters Alpha-Band Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Human Sensory Cortex Contributes to the Long-Term Storage of Aversive Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Fear conditioning prompts sparser representations of conditioned threat in primary visual cortex.Social cognitive and affective neuroscience · 2020Article
- Negative content enhances stimulus-specific cerebral activity during free viewing of pictures, faces, and words.Human brain mapping · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Emotionally salient cues are detected more readily, remembered better, and evoke greater visual cortical responses compared with neutral stimuli. The current study used concurrent EEG-fMRI recordings to identify large-scale network interactions involved in the amplification of visual cortical activity when viewing aversively conditioned cues. To generate a continuous neural signal from pericalcarine visual cortex, we presented rhythmic (10/sec) phase-reversing gratings, the orientation of which predicted the presence (CS+) or absence (CS-) of a cutaneous electric shock (i.e., the unconditioned stimulus). The resulting single trial steady-state visual evoked potential (ssVEP) amplitude was regressed against the whole-brain BOLD signal, resulting in a measure of ssVEP-BOLD coupling. Across all trial types, ssVEP-BOLD coupling was observed in both primary and extended visual cortical regions, the rolandic operculum, as well as the thalamus and bilateral hippocampus. For CS+ relative to CS- trials during the conditioning phase, BOLD-alone analyses showed CS+ enhancement at the occipital pole, superior temporal sulci, and the anterior insula bilaterally, whereas ssVEP-BOLD coupling was greater in the pericalcarine cortex, inferior parietal cortex, and middle frontal gyrus. Dynamic causal modeling analyses supported connectivity models in which heightened activity in pericalcarine cortex for threat (CS+) arises from cortico-cortical top-down modulation, specifically from the middle frontal gyrus. No evidence was observed for selective pericalcarine modulation by deep cortical structures such as the amygdala or anterior insula, suggesting that the heightened engagement of pericalcarine cortex for threat stimuli is mediated by cortical structures that constitute key nodes of canonical attention networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.