Evidence map›Paper›PMID 28252802›Full record

ArticleAllergy2017

Pru p 3, a marker allergen for lipid transfer protein sensitization also in Central Europe.

N Mothes-Luksch, M Raith, G Stingl, M Focke-Tejkl, E Razzazi-Fazeli, R Zieglmayer, S Wöhrl, I Swoboda

Open access · hybridAbstract read
In one paragraph

Article in Allergy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. IgE-mediated lipid transfer protein allergy in children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Review
  7. Review
  8. The Diagnosis of Allergy to Lipid Transfer Proteins.Current allergy and asthma reports · 2024
    Review
  9. Article
  10. Article
  11. Basophil Activation Test Utility as a Diagnostic Tool in LTP Allergy.International journal of molecular sciences · 2022
    Article
  12. Review
  13. Article
  14. Skin Prick Testing Predicts Peach Hypersensitivity Reactions.Allergy, asthma & immunology research · 2021
    Article
  15. Skin Testing With Peach Peel ExtractAllergy, asthma & immunology research · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Recent advances in the management of nut allergy.The World Allergy Organization journal · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

N Mothes-LukschComparative Immunology and Oncology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
M RaithMolecular Biotechnology Section, FH Campus Wien, University of Applied Sciences, Campus Vienna Biocenter, Vienna, Austria.
G StinglDepartment of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Medical University of Vienna, Vienna, Austria.
M Focke-TejklDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
E Razzazi-FazeliVetCore Facility for Research, University of Veterinary Medicine Vienna, Vienna, Austria.
R ZieglmayerVienna Challenge Chamber, Vienna, Austria.
S WöhrlFAZ - Floridsdorf Allergy Center, Vienna, Austria.
I SwobodaMolecular Biotechnology Section, FH Campus Wien, University of Applied Sciences, Campus Vienna Biocenter, Vienna, Austria.ORCID http://orcid.org/0000-0002-9164-1721
Medical University of Vienna · ATHochschule Campus Wien · ATAllergiezentrum Wien West · ATUniversity of Veterinary Medicine Vienna · ATVienna Challenge Chamber · AT

Funding

Austrian Science Fund FWF P 25868
6 · The paper itself

Abstract

In the Mediterranean area, lipid transfer proteins (LTPs) are important causes of plant-food allergies often associated with severe allergic reactions. There, peach LTP (Pru p 3) seems to be the primary sensitizer, whereas in Central Europe, little is known about the importance of LTP sensitization. In this region, allergen extract-based diagnosis is often complicated by co-sensitization to Bet v 1, the major birch pollen allergen, its cross-reactive food allergens, and profilins. We investigated the role of LTP sensitization in Central European patients displaying strong allergic reactions to plant-derived food. Analysis of IgE reactivity revealed that ten of thirteen patients were sensitized to Pru p 3, nine to Bet v 1, and two to profilin. Our results showed that LTP sensitization represents a risk factor for severe allergic symptoms in Central Europe. Furthermore, the strong IgE reactivity detected in immunoblots of plant-food extracts indicated that Pru p 3 can be used as a marker allergen for LTP sensitization also in Central European patients.

Indexed as

Antigens, PlantBiomarkersCarrier ProteinsCross ReactionsEuropeFood HypersensitivityHumansImmunoglobulin EPlant ProteinsProfilinsAntigens, PlantBiomarkersCarrier ProteinsImmunoglobulin Elipid transfer proteinPlant ProteinsProfilinsPru p 3 allergencomponent resolved diagnosisfood allergyimmunologic testslipid transfer proteinPru p 3

Identifiers

PMID28252802
PMCPMC5573991
OpenAlexW2594638449

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.