Evidence map›Paper›PMID 28252570›Full record

ArticleNursing research

Potassium Channel Candidate Genes Predict the Development of Secondary Lymphedema Following Breast Cancer Surgery.

Betty Smoot, Kord M Kober, Steven M Paul, Jon D Levine, Gary Abrams, Judy Mastick, Kimberly Topp, Yvette P Conley, Christine A Miaskowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nursing research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Etiology and treatment of cancer-related secondary lymphedema.Clinical & experimental metastasis · 2024
    Review
  5. Secondary lymphedema from cancer therapy.Clinical & experimental metastasis · 2022
    Review
  6. Article
  7. Review
  8. Lymphedema following cancer therapy: overview and options.Clinical & experimental metastasis · 2018
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 3 countries.

Betty SmootBetty Smoot, PT, DPTSc, MAS, is Associate Professor, School of Medicine, University of California San Francisco. Kord M. Kober, PhD, is Assistant Professor; and Steven M. Paul, PhD, is Principal Statistician, School of Nursing, University of California San Francisco. Jon D. Levine, MD, is Professor; and Gary Abrams, MD, is Professor, School of Medicine, University of California San Francisco. Judy Mastick, RN, MN, is Project Director, School of Nursing, University of California San Francisco. Kimberly Topp, PT, PhD, is Professor, School of Medicine, University of California San Francisco. Yvette P. Conley, PhD, FAAN, is Professor, School of Nursing, University of Pittsburgh, Pennsylvania. Christine Miaskowski, PhD, RN, FAAN, is Professor, School of Nursing, University of California San Francisco.
Kord M Kober
Steven M Paul
Jon D Levine
Gary Abrams
Judy Mastick
Kimberly Topp
Yvette P Conley
Christine A Miaskowski
Apple (Israel) · IL

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Symptom Management After Breast Cancer SurgeryR01CA107091 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2003 to 2008
$4.5M
Long-term Arm Morbidity Following Breast Cancer TreatmentR01CA118658 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2006 to 2010
$3.5M
Advancing the Science of Symptom Management in Oncology PatientsK05CA168960 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2013 to 2017
$453k
NCI NIH HHS K05 CA168960NCI NIH HHS R01 CA107091NCI NIH HHS R01 CA118658NCRR NIH HHS UL1 RR024131
6 · The paper itself

Abstract

backgroundPotassium (K) channels play an important role in lymph pump activity, lymph formation, lymph transport, and the functions of lymph nodes. No studies have examined the relationship between K channel candidate genes and the development of secondary lymphedema (LE).

objectiveThe study purpose was to evaluate for differences in genotypic characteristics in women who did (n = 155) or did not (n = 387) develop upper extremity LE following breast cancer treatment based on an analysis of single-nucleotide polymorphisms (SNPs) and haplotypes in 10 K channel genes.

methodsUpper extremity LE was diagnosed using bioimpedance resistance ratios. Logistic regression analyses were used to identify those SNPs and haplotypes that were associated with LE while controlling for relevant demographic, clinical, and genomic characteristics.

resultsPatients with LE had a higher body mass index, had a higher number of lymph nodes removed, had more advanced disease, received adjuvant chemotherapy, received radiation therapy, and were less likely to have undergone a sentinel lymph node biopsy. One SNP in a voltage-gated K channel gene (KCNA1 rs4766311), four in two inward-rectifying K channel genes (KCNJ3 rs1037091 and KCNJ6 rs2211845, rs991985, rs2836019), and one in a two-pore K channel gene (KCNK3 rs1662988) were associated with LE. DISCUSSION: These preliminary findings suggest that K channel genes play a role in the development of secondary LE.

Indexed as

AdultBody Mass IndexBreast NeoplasmsFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenetic TestingHumansLymphedemaMiddle AgedPolymorphism, Single NucleotidePotassium Channels, Voltage-GatedPotassium Channels, Voltage-Gated

Identifiers

PMID28252570
PMCPMC5334662
OpenAlexW2594853694

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.