Evidence map›Paper›PMID 28252202›Full record

ArticleCurrent protocols in mouse biology2017

A Mouse Model for Ocular Surface Staphylococcus aureus Infection.

Zhiyong Zhang, Osama Abdel-Razek, Guirong Wang

Open access · greenAbstract read
In one paragraph

Article in Current protocols in mouse biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Zhiyong ZhangDepartment of Surgery, The State University of New York Upstate Medical University, Syracuse, New York.
Osama Abdel-RazekDepartment of Surgery, The State University of New York Upstate Medical University, Syracuse, New York.
Guirong WangDepartment of Surgery, The State University of New York Upstate Medical University, Syracuse, New York.
SUNY Upstate Medical University · USHangzhou Medical College · CN

Funding

Mechanisms of 5'UTR splicing of human surfactant protein (SP)-A1 and SP-A2R21HL096007 · NHLBI · UPSTATE MEDICAL UNIVERSITY · PI WANG, GUIRONG · 2010 to 2011
$427k
NHLBI NIH HHS R21 HL096007
6 · The paper itself

Abstract

Creation of an appropriate animal model that accurately reflects the disease and host immune response to bacterial infection in humans is a major challenge in ocular-surface infection research. For decades, mice have been the ideal small animal model for ocular-surface infection research because of the availability and relatively low cost of various genetic backgrounds, targeted defects, and immunologic reagents. By employing different combinations of mouse and bacterial strains, murine infection models can be used to explore a complete picture of bacterial infection and innate immunity of the ocular surface. A murine model of Staphylococcus aureus infection under normal ocular circumstances is presented here as a convenient and tractable model system in which to study mammalian host responses to pathogens. © 2017 by John Wiley & Sons, Inc.

Indexed as

Disease Models, AnimalAnimalsEpithelial CellsEye InfectionsHost-Pathogen InteractionsHumansImmunity, InnateMiceNeutrophilsPhagocytosisStaphylococcal InfectionsStaphylococcus aureusSurface PropertiescorneaeyeinfectionStaphylococcus aureus, host defense

Identifiers

PMID28252202
PMCPMC5334776
OpenAlexW2592359431

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.