Evidence map›Paper›PMID 28252051›Full record

ArticleScientific reports2017

Determination of the pK

Alain Oregioni, Benjamin Stieglitz, Geoffrey Kelly, Katrin Rittinger, Tom Frenkiel

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  3. 7-[Journal of medicinal chemistry · 2023
    Article
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  8. Selenolysine: A New Tool for Traceless Isopeptide Bond Formation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020
    Article
  9. Threats to adhesive/dentin interfacial integrity and next generation bio-enabled multifunctional adhesives.Journal of biomedical materials research. Part B, Applied biomaterials · 2019
    Review
  10. Article
  11. Article
  12. Modulating pH through lysine integrated dental adhesives.Dental materials : official publication of the Academy of Dental Materials · 2018
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alain OregioniMRC Biomedical NMR Centre, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Benjamin StieglitzMolecular Structure of Cell Signalling Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Geoffrey KellyMRC Biomedical NMR Centre, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Katrin RittingerMolecular Structure of Cell Signalling Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Tom FrenkielMRC Biomedical NMR Centre, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
The Francis Crick Institute · GB

Funding

Cancer Research UK FC001142Cancer Research UK FC10029Medical Research Council MC_U117533887Medical Research Council MC_U117565398Wellcome Trust
6 · The paper itself

Abstract

Ubiquitination regulates nearly every aspect of cellular life. It is catalysed by a cascade of three enzymes and results in the attachment of the C-terminal carboxylate of ubiquitin to a lysine side chain in the protein substrate. Chain extension occurs via addition of subsequent ubiquitin molecules to either one of the seven lysine residues of ubiquitin, or via its N-terminal α-amino group to build linear ubiquitin chains. The pK

Indexed as

Protein Interaction Domains and MotifsCatalytic DomainHumansHydrogen-Ion ConcentrationKineticsMagnetic Resonance SpectroscopyModels, MolecularProtein ConformationUbiquitinUbiquitinationUbiquitin

Identifiers

PMID28252051
PMCPMC5333110
OpenAlexW2592608913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.