ArticleScientific reports2017
Moderate dietary protein restriction alters the composition of gut microbiota and improves ileal barrier function in adult pig model.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
175 citing papers in PubMed, 3 syntheses or guidelines pooled it, 344 citations in OpenAlex.
- Pooled it
- Diet, adiposity, and the gut microbiota from infancy to adolescence: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- The Human Microbiota and Obesity: A Literature Systematic Review of In Vivo Models and Technical Approaches.International journal of molecular sciences · 2018Pooled it
- Association of metformin administration with gut microbiome dysbiosis in healthy volunteers.PloS one · 2018Trial
- Review
- Dietary Arginine Supplementation Modulates Nitrogen Utilization, Serum Biochemistry, and Gut Microbiota in Growing Beagles Under Low- and Normal-Protein Diets.Animals : an open access journal from MDPI · 2026Article
- Soft-Pellet Feed Strategy for Broilers: Effects on Growth Performance and Liver-Intestinal Health.Animals : an open access journal from MDPI · 2026Article
- A manually curated pig gut microbiome dataset for precision feeding.Scientific data · 2026Article
- Diet Outweighs Vertical Transmission in Shaping Dung Beetle Larval Gut Microbiomes.Molecular ecology · 2026Article
- Associations Between Fine Particulate Matter-Associated Bacteria and Respiratory Tract Microbiota in Pigs.Animals : an open access journal from MDPI · 2026Article
- Butyrate supplementation in sows promotes offspring embryonic muscle development by upregulating HDAC-mediated H3K27ac levels and myogenic gene expression.Science China. Life sciences · 2026Article
- Impact of low-crude protein and insoluble fiber diets on post-weaning diarrhea, growth performance, intestinal morphology, and gene expression for nursery pigs with natural rotavirus and subject to enterotoxigenicTranslational animal science · 2026Article
- Diet-induced metabolic and faecal microbiome responses in pet dogs fed a minimally processed versus extruded kibble diet.Frontiers in veterinary science · 2026Article
- Effects of Dietary Crude Protein Level on Growth Performance, Carcass Traits, Meat Quality, and Fatty Acid Composition of Ningxiang Finishing Pigs.Animals : an open access journal from MDPI · 2025Article
- Effects of Dietary Potassium Diformate Supplementation on Growth Performance, Nutrient Digestibility, Gastrointestinal pH, Jejunal Morphology, Digestive Enzyme Activity, and Antioxidant Status in Weaned Piglets.Animals : an open access journal from MDPI · 2025Article
- A new in vitro model of the adult pig colon microbiome: application to the study of feed ingredients.Animal microbiome · 2025Article
- Effect of calf separation on gut microbiome and fecal metabolome of mother in the captive Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis).International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Understanding how foods and enteral feedings influence the gut microbiome.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025Review
- Glutamate Supplementation Regulates Nitrogen Metabolism in the Colon and Liver of Weaned Rats Fed a Low-Protein Diet.Nutrients · 2025Article
- Differences in Microbial Community Structure Determine the Functional Specialization of Gut Segments ofMicroorganisms · 2025Article
115 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was conducted to investigate impacts of dietary protein levels on gut bacterial community and gut barrier. The intestinal microbiota of finishing pigs, fed with 16%, 13% and 10% crude protein (CP) in diets, respectively, were investigated using Illumina MiSeq sequencing. The ileal bacterial richness tended to decrease when the dietary protein concentration reduced from 16% to 10%. The proportion of Clostridium_sensu_stricto_1 in ileum significantly decreased, whereas Escherichia-Shigella increased with reduction of protein concentration. In colon, the proportion of Clostridium_sensu_stricto_1 and Turicibacter increased, while the proportion of RC9_gut_group significantly decreased with the dietary protein reduction. Notably, the proportion of Peptostreptococcaceae was higher in both ileum and colon of 13% CP group. As for metabolites, the intestinal concentrations of SCFAs and biogenic amines decreased with the dietary protein reduction. The 10% CP dietary treatment damaged ileal mucosal morphology, and decreased the expression of biomarks of intestinal cells (Lgr5 and Bmi1), whereas the expression of tight junction proteins (occludin and claudin) in 13% CP group were higher than the other two groups. In conclusion, moderate dietary protein restriction (13% CP) could alter the bacterial community and metabolites, promote colonization of beneficial bacteria in both ileum and colon, and improve gut barrier function.
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