ArticleScientific reports2017
An antimicrobial peptide-resistant minor subpopulation of Photorhabdus luminescens is responsible for virulence.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 30 citations in OpenAlex.
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- Effects of Microorganisms on Growth Performance, Body Composition, Digestive Enzyme Activity, Intestinal Bacteria Flora and Antimicrobial Peptide (AMP) Content of Black Soldier Fly Larvae (Animals : an open access journal from MDPI · 2023Article
- Navigating Environmental Transitions: the Role of Phenotypic Variation in Bacterial Responses.mBio · 2022Review
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- How the PhoP/PhoQ System Controls Virulence and MgMicrobiology and molecular biology reviews : MMBR · 2021Review
- Pseudomonas syringae pv.mBio · 2021Article
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- Role of the Photorhabdus Dam methyltransferase during interactions with its invertebrate hosts.PloS one · 2019Article
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- The complete methylome of an entomopathogenic bacterium reveals the existence of loci with unmethylated Adenines.Scientific reports · 2018Article
- Allatostatin C modulates nociception and immunity in Drosophila.Scientific reports · 2018Article
- A high-frequency phenotypic switch links bacterial virulence and environmental survival in Acinetobacter baumannii.Nature microbiology · 2018Article
- Analysis ofFrontiers in microbiology · 2017Article
- DNA Adenine Methyltransferase (Dam) Overexpression ImpairsFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some of the bacterial cells in isogenic populations behave differently from others. We describe here how a new type of phenotypic heterogeneity relating to resistance to cationic antimicrobial peptides (CAMPs) is determinant for the pathogenic infection process of the entomopathogenic bacterium Photorhabdus luminescens. We demonstrate that the resistant subpopulation, which accounts for only 0.5% of the wild-type population, causes septicemia in insects. Bacterial heterogeneity is driven by the PhoPQ two-component regulatory system and expression of pbgPE, an operon encoding proteins involved in lipopolysaccharide (LPS) modifications. We also report the characterization of a core regulon controlled by the DNA-binding PhoP protein, which governs virulence in P. luminescens. Comparative RNAseq analysis revealed an upregulation of marker genes for resistance, virulence and bacterial antagonism in the pre-existing resistant subpopulation, suggesting a greater ability to infect insect prey and to survive in cadavers. Finally, we suggest that the infection process of P. luminescens is based on a bet-hedging strategy to cope with the diverse environmental conditions experienced during the lifecycle.
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