Evidence map›Paper›PMID 28251989›Full record

ArticleScientific reports2017

Silver nanoparticles reduce brain inflammation and related neurotoxicity through induction of H

Daniel A Gonzalez-Carter, Bey Fen Leo, Pakatip Ruenraroengsak, Shu Chen, Angela E Goode, Ioannis G Theodorou, Kian Fan Chung, Raffaella Carzaniga, Milo S P Shaffer, David T Dexter and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 161 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Daniel A Gonzalez-CarterDepartment of Materials and London Centre for Nanotechnology, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.
Bey Fen LeoDepartment of Materials and London Centre for Nanotechnology, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.
Pakatip RuenraroengsakDepartment of Materials and London Centre for Nanotechnology, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.
Shu ChenDepartment of Materials and London Centre for Nanotechnology, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.
Angela E GoodeDepartment of Materials and London Centre for Nanotechnology, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.
Ioannis G TheodorouDepartment of Materials and London Centre for Nanotechnology, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.
Kian Fan ChungNational Heart and Lung Institute, Imperial College London, Guy Scadding Building, Cale Street, London, SW3 6LY, UK.
Raffaella CarzanigaElectron Microscopy Science Technology Platform, The Francis Crick Institute, Lincoln's Inn Fields Laboratory, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK.
Milo S P ShafferDepartment of Materials and London Centre for Nanotechnology, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.
David T DexterParkinson's Disease Research Unit, Centre for Neuroinflammation and Neurodegeneration, Division of Brain Sciences, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK.
Mary P RyanDepartment of Materials and London Centre for Nanotechnology, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.
Alexandra E PorterDepartment of Materials and London Centre for Nanotechnology, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.
Imperial College London · GBLondon Centre for Nanotechnology · GBThe Francis Crick Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silver nanoparticles (AgNP) are known to penetrate into the brain and cause neuronal death. However, there is a paucity in studies examining the effect of AgNP on the resident immune cells of the brain, microglia. Given microglia are implicated in neurodegenerative disorders such as Parkinson's disease (PD), it is important to examine how AgNPs affect microglial inflammation to fully assess AgNP neurotoxicity. In addition, understanding AgNP processing by microglia will allow better prediction of their long term bioreactivity. In the present study, the in vitro uptake and intracellular transformation of citrate-capped AgNPs by microglia, as well as their effects on microglial inflammation and related neurotoxicity were examined. Analytical microscopy demonstrated internalization and dissolution of AgNPs within microglia and formation of non-reactive silver sulphide (Ag

Indexed as

AnimalsCell LineCell SurvivalCystathionine gamma-LyaseEncephalitisGene Expression Regulation, EnzymologicHydrogen SulfideLipopolysaccharidesMetal NanoparticlesMiceMicrogliaModels, BiologicalNeuronsNeurotoxicity SyndromesOxidative StressSilverCystathionine gamma-LyaseHydrogen SulfideLipopolysaccharidesSilver

Identifiers

PMID28251989
PMCPMC5333087
OpenAlexW2592398464

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.