ArticleMolecular biology of the cell2017
Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1-fibronectin links.
Article in Molecular biology of the cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Transcriptomic analysis of zonula occludens-1 (ZO-1) knockout in ovarian cancer cell lines.Genes & genomics · 2026Article
- Chicken Primordial Germ Cells Do Not Proliferate in Insulin-Lacking Media.International journal of molecular sciences · 2025Article
- Turn-on protein switches for controlling actin binding in cells.Nature communications · 2024Article
- Turn-On Protein Switches for Controlling Actin Binding in Cells.bioRxiv : the preprint server for biology · 2023Article
- Article
- New perspectives on integrin-dependent adhesions.Current opinion in cell biology · 2020Review
- Integrin Binding Dynamics Modulate Ligand-Specific Mechanosensing in Mammary Gland Fibroblasts.iScience · 2020Article
- ZO-1 associates with α3 integrin and connexin43 in trabecular meshwork and Schlemm's canal cells.International journal of physiology, pathophysiology and pharmacology · 2020Article
- Gap junction connexin43 is a key element in mediating phagocytosis activity in human trabecular meshwork cells.International journal of physiology, pathophysiology and pharmacology · 2020Article
- Integrins as biomechanical sensors of the microenvironment.Nature reviews. Molecular cell biology · 2019Review
- Gold Nanorod Photothermal Therapy Alters Cell Junctions and Actin Network in Inhibiting Cancer Cell Collective Migration.ACS nano · 2018Article
- Every step of the way: integrins in cancer progression and metastasis.Nature reviews. Cancer · 2018Review
- Cell and tissue mechanics: the new cell biology frontier.Molecular biology of the cell · 2017Article
- Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) promote neurorepair in the ischemic brain.Receptors & clinical investigation · 2017Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fundamental processes in cell adhesion, motility, and rigidity adaptation are regulated by integrin-mediated adhesion to the extracellular matrix (ECM). The link between the ECM component fibronectin (fn) and integrin α5β1 forms a complex with ZO-1 in cells at the edge of migrating monolayers, regulating cell migration. However, how this complex affects the α5β1-fn link is unknown. Here we show that the α5β1/ZO-1 complex decreases the resistance to force of α5β1-fn adhesions located at the edge of migrating cell monolayers while also increasing α5β1 recruitment. Consistently with a molecular clutch model of adhesion, this effect of ZO-1 leads to a decrease in the density and intensity of adhesions in cells at the edge of migrating monolayers. Taken together, our results unveil a new mode of integrin regulation through modification of the mechanical properties of integrin-ECM links, which may be harnessed by cells to control adhesion and migration.
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