Evidence map›Paper›PMID 28251921›Full record

ReviewNeurology2017

Clinical implications of the melanopsin-based non-image-forming visual system.

Alexander Ksendzovsky, I Jonathan Pomeraniec, Kareem A Zaghloul, J Javier Provencio, Ignacio Provencio

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Photoperiodic physiology of summer breeding birds and a search for the role of eye.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. The circadian clock and metabolic homeostasis: entangled networks.Cellular and molecular life sciences : CMLS · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander KsendzovskyFrom the Departments of Neurological Surgery (A.K., I.J.P.) and Neurology and Neuroscience (J.J.P.), University of Virginia Health Sciences Center, Charlottesville; Surgical Neurology Branch (A.K., K.A.Z.), National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, MD; and the Departments of Molecular Physiology and Biological Physics (A.K.) and Biology (I.P.), University of Virginia, Charlottesville. alex@virginia.edu.
I Jonathan PomeraniecFrom the Departments of Neurological Surgery (A.K., I.J.P.) and Neurology and Neuroscience (J.J.P.), University of Virginia Health Sciences Center, Charlottesville; Surgical Neurology Branch (A.K., K.A.Z.), National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, MD; and the Departments of Molecular Physiology and Biological Physics (A.K.) and Biology (I.P.), University of Virginia, Charlottesville.
Kareem A ZaghloulFrom the Departments of Neurological Surgery (A.K., I.J.P.) and Neurology and Neuroscience (J.J.P.), University of Virginia Health Sciences Center, Charlottesville; Surgical Neurology Branch (A.K., K.A.Z.), National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, MD; and the Departments of Molecular Physiology and Biological Physics (A.K.) and Biology (I.P.), University of Virginia, Charlottesville.
J Javier ProvencioFrom the Departments of Neurological Surgery (A.K., I.J.P.) and Neurology and Neuroscience (J.J.P.), University of Virginia Health Sciences Center, Charlottesville; Surgical Neurology Branch (A.K., K.A.Z.), National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, MD; and the Departments of Molecular Physiology and Biological Physics (A.K.) and Biology (I.P.), University of Virginia, Charlottesville.
Ignacio ProvencioFrom the Departments of Neurological Surgery (A.K., I.J.P.) and Neurology and Neuroscience (J.J.P.), University of Virginia Health Sciences Center, Charlottesville; Surgical Neurology Branch (A.K., K.A.Z.), National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, MD; and the Departments of Molecular Physiology and Biological Physics (A.K.) and Biology (I.P.), University of Virginia, Charlottesville.

Funding

Investigating the neural mechanisms of human cognitive function through intracranial recordingsZIANS003144 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ZAGHLOUL, KAREEM · 2014 to 2025
$36.1M
6 · The paper itself

Abstract

Since the discovery of the non-image-forming visual system, tremendous research efforts have been dedicated to understanding its mechanisms and functional roles. Original functions associated with the melanopsin system include the photoentrainment of circadian sleep-wake cycles and the pupillary light reflex. Recent findings, however, suggest a much broader involvement of this system in an array of physiologic responses to light. This newfound insight into the underlying function of the non-image-forming system has revealed the many connections to human pathology and attendant disease states, including seasonal affective disorder, migraine, glaucoma, inherited mitochondrial optic neuropathy, and sleep dysregulation of aging. In this review, the authors discuss in detail the clinical implications of the melanopsin system.

Indexed as

Eye DiseasesAnimalsCircadian RhythmHumansLightMelanopsinPhotophobiaRod OpsinsSeasonal Affective DisorderSleep Wake DisordersVisual PathwaysMelanopsinRod Opsins

Identifiers

PMID28251921
PMCPMC5373779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.