ArticleBlood2017
Elevated hematocrit enhances platelet accumulation following vascular injury.
Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Testosterone therapy and venous thromboembolism: A systematic review and meta-analysis.Thrombosis research · 2018Pooled it
- Prepartum Anemia and Risk of Postpartum Hemorrhage: A Meta-Analysis and Brief Review.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- Anemone study: prevalence of risk factors for superficial vein thrombosis in a large Italian population of blood donors.Journal of thrombosis and thrombolysis · 2020Trial
- Hypoxia suppresses platelet activity through GPVI down-regulation but paradoxically enhances arterial thrombosis via elevated vWF.Cardiovascular research · 2026Article
- Bio-inspired programmable assembly of shape-memory and blood-reinforced cryogel for hemostasis and functional liver regeneration.Materials today. Bio · 2026Article
- Erythrocytosis after SGLT2 inhibitor initiation and anticoagulated outcomes in atrial fibrillation: a real-world analysis with counterfactual modeling.Cardiovascular diabetology · 2026Article
- Clinical and Molecular Insights of Arterial and Venous Thrombosis in Myeloproliferative Diseases-Case-Based Narrative Review.Biomedicines · 2025Review
- Article
- Maize stover burning exposure accountable for remarkable environmental and health risk in broiler chickens.BMC veterinary research · 2025Article
- Atrial fibrillation in Retinal Artery Occlusions.Cardiology and cardiovascular medicine · 2025Article
- Relationships of hematocrit concentration with dementia from a multiethnic population-based study.Frontiers in aging neuroscience · 2025Article
- Correlation between the hemoglobin-to-hematocrit ratio and 3-month outcomes in patients with acute ischemic stroke: a secondary analysis based on a prospective cohort study.Frontiers in neurology · 2025Article
- Impact ofEJHaem · 2024Article
- Factors that modulate platelet reactivity as measured by 5 assay platforms in 3429 individuals.Research and practice in thrombosis and haemostasis · 2024Article
- Blood failure: traumatic hemorrhage and the interconnections between oxygen debt, endotheliopathy, and coagulopathy.Clinical and experimental emergency medicine · 2024Article
- Review
- Influence of Hematocrit Level and Integrin αCellular and molecular bioengineering · 2024Article
- Red Blood Cell Contribution to Thrombosis in Polycythemia Vera and Essential Thrombocythemia.International journal of molecular sciences · 2024Review
- Relationships of Hematocrit With Chronic Covert and Acute Symptomatic Lacunar Ischemic Lesions.Neurology · 2024Observational
- Idiopathic erythrocytosis: a germline disease?Clinical and experimental medicine · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
Abstract
Red blood cells (RBCs) demonstrate procoagulant properties in vitro, and elevated hematocrit is associated with reduced bleeding and increased thrombosis risk in humans. These observations suggest RBCs contribute to thrombus formation. However, effects of RBCs on thrombosis are difficult to assess because humans and mice with elevated hematocrit typically have coexisting pathologies. Using an experimental model of elevated hematocrit in healthy mice, we measured effects of hematocrit in 2 in vivo clot formation models. We also assessed thrombin generation, platelet-thrombus interactions, and platelet accumulation in thrombi ex vivo, in vitro
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.