ArticleBMC bioinformatics2017
Virtual reality assisted microscopy data visualization and colocalization analysis.
Article in BMC bioinformatics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The virus lesson: Teaching viral structure and quasi-symmetry in mixed reality.Protein science : a publication of the Protein Society · 2026Article
- Virtual reality-augmented differentiable simulations for digital twin applications in surgical planning.Scientific reports · 2025Article
- ColocZStats: a z-stack signal colocalization extension tool for 3D slicer.Frontiers in physiology · 2024Article
- Colocalization Analysis of Cytoplasmic Actin Isoforms Distribution in Endothelial Cells.Biomedicines · 2022Article
- SpotitPy: a semi-automated tool for object-based co-localization of fluorescent labels in microscopy images.BMC bioinformatics · 2022Article
- A data-centric artificial intelligent and extended reality technology in smart healthcare systems.Social network analysis and mining · 2022Review
- A Novel Gesture-Based Control System for Fluorescence Volumetric Data in Virtual Reality.Sensors (Basel, Switzerland) · 2021Article
- CellexalVR: A virtual reality platform to visualize and analyze single-cell omics data.iScience · 2021Article
- Virtual and augmented reality for biomedical applications.Cell reports. Medicine · 2021Review
- New Approach to Accelerated Image Annotation by Leveraging Virtual Reality and Cloud Computing.Frontiers in bioinformatics · 2021Article
- vLUME: 3D virtual reality for single-molecule localization microscopy.Nature methods · 2020Article
- Accuracy and Reproducibility of Linear and Angular Measurements in Virtual Reality: a Validation Study.Journal of digital imaging · 2020Article
- BioVR: a platform for virtual reality assisted biological data integration and visualization.BMC bioinformatics · 2019Article
- Article
- Comparative analysis of tissue reconstruction algorithms for 3D histology.Bioinformatics (Oxford, England) · 2018Article
- Article
- Integrating light-sheet imaging with virtual reality to recapitulate developmental cardiac mechanics.JCI insight · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConfocal microscopes deliver detailed three-dimensional data and are instrumental in biological analysis and research. Usually, this three-dimensional data is rendered as a projection onto a two-dimensional display. We describe a system for rendering such data using a modern virtual reality (VR) headset. Sample manipulation is possible by fully-immersive hand-tracking and also by means of a conventional gamepad. We apply this system to the specific task of colocalization analysis, an important analysis tool in biological microscopy. We evaluate our system by means of a set of user trials.
resultsThe user trials show that, despite inaccuracies which still plague the hand tracking, this is the most productive and intuitive interface. The inaccuracies nevertheless lead to a perception among users that productivity is low, resulting in a subjective preference for the gamepad. Fully-immersive manipulation was shown to be particularly effective when defining a region of interest (ROI) for colocalization analysis.
conclusionsVirtual reality offers an attractive and powerful means of visualization for microscopy data. Fully immersive interfaces using hand tracking show the highest levels of intuitiveness and consequent productivity. However, current inaccuracies in hand tracking performance still lead to a disproportionately critical user perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.