Evidence map›Paper›PMID 28251861›Full record

SynthesisTopics in stroke rehabilitation2017

Skeletal muscle changes following stroke: a systematic review and comparison to healthy individuals.

Jennifer L Hunnicutt, Chris M Gregory

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Topics in stroke rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 7 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 7 syntheses or guidelines pooled it, 127 citations in OpenAlex.

  1. Pooled it
  2. Peripheral vascular function in stroke: systematic review and meta-analysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
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  18. Body Composition Alterations in Patients with Chronic Stroke: A Cross-Sectional Study.Journal of musculoskeletal & neuronal interactions · 2025
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  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jennifer L Hunnicutta Health Sciences and Research , Medical University of South Carolina , Charleston , SC , USA.ORCID 0000-0001-7588-6676
Chris M Gregorya Health Sciences and Research , Medical University of South Carolina , Charleston , SC , USA.
Medical University of South Carolina · US

Funding

Treating Depression and Enhancing Locomotor Recovery Post-strokeP20GM109040 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KAUTZ, STEVEN A. · 2014 to 2024
$23.5M
Skeletal Muscle Plasticity As An Indicator of Functional Performance Post-StrokeI01RX000844 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI GREGORY, CHRIS · 2014 to 2017
–
NIGMS NIH HHS P20 GM109040RRD VA I01 RX000844
6 · The paper itself

Abstract

backgroundDespite extensive study of the impact of stroke on muscle and functional performance, questions remain regarding the extent to which changes are due to the neurological injury vs. age-related loss of morphology and force production.

objectivesTo synthesize available evidence describing post-stroke changes in lower extremity muscle size and strength compared to healthy adults.

methodsScientific literature was searched up to April 2016 to identify studies that included lower extremity muscle size and strength measures in individuals with chronic stroke. Lower extremity muscle size and strength data from healthy controls were sought for comparison. Relative differences were calculated between paretic, nonparetic, and control limbs.

resultsFifteen studies with 375 participants (61% male; age = 62 ± 5 years; time since stroke = 60 ± 42 months) were included. The paretic limb exhibited deficits of ~13% in thigh muscle size, ~5% in lower leg muscle size, and ~8% in lean leg mass compared to the nonparetic limb. Paretic plantarflexor and knee extensor strength were 52 and 36% lower, respectively, compared to the nonparetic limb. When compared to age-matched control data, both paretic and nonparetic limbs showed deficits in muscle size and strength.

conclusionsAge-related differences support the impact of stroke-related sarcopenia as a contributor to hemiparetic muscle dysfunction. Understanding these muscular changes is necessary for designing appropriate exercise interventions aimed at restoring muscle function.

Indexed as

AgedDatabases, BibliographicFemaleHumansLower ExtremityMaleMiddle AgedMuscle, SkeletalStrokeStroke Rehabilitationmusclemuscle massrehabilitationsarcopeniastrengthStrokesystematic review

Identifiers

PMID28251861
PMCPMC5801663
OpenAlexW2612372767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.