Evidence map›Paper›PMID 28251687›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2017

Fracture Risk After Bariatric Surgery: Roux-en-Y Gastric Bypass Versus Adjustable Gastric Banding.

Elaine W Yu, Moa P Lee, Joan E Landon, Katherine G Lindeman, Seoyoung C Kim

2 registry-linked trialsAbstract readComparative Study
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
18.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04174495 completednot on this mapstarted 2020, after this paper: background citation

Bone Fragility Evaluation by Dual X-Ray Absorptiometry (DXA) and CT-scan (vertebral Fracture and Scanographic Bone Attenuation Coefficient of the First Lumbar Vertebra SBAC-L1) in Obese Patients

TypeobservationalSponsorCentral Hospital, Nancy, FranceRan2020 to 2021Enrolled1,500ConditionsObesity, Bariatric Surgery CandidateArmsDXA and CT-scan
NCT04742010 phase2completednot on this mapstarted 2021, after this paper: background citation

Zoledronic Acid for Prevention of Bone Loss After BAriatric Surgery (ZABAS)

TypeinterventionalSponsorStinus Gadegaard HansenRan2021 to 2024Enrolled59ConditionsBone Loss, Muscle Atrophy, Bariatric SurgeryArmsZoledronic Acid, Placebo
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.

  1. Changes in volumetric bone mineral density and bone quality after Roux-en-Y gastric bypass: A meta-analysis with meta-regression.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Pooled it
  2. Fracture risk following bariatric surgery: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Pooled it
  3. Trial
  4. Effect of catgut embedding at acupoints versus non-acupoints in abdominal obesity: a randomized clinical trial.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023
    Trial
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  14. Fat as a Friend or Foe of the Bone.Current osteoporosis reports · 2024
    Review
  15. Risk of wrist fracture, estimated by the load-to-strength ratio, declines following sleeve gastrectomy in adolescents and young adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Article
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  17. Observational
  18. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Elaine W YuEndocrine Unit, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0633-0839
Moa P LeeDivision of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
Joan E LandonDivision of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
Katherine G LindemanEndocrine Unit, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Seoyoung C KimDivision of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
Brigham and Women's Hospital · USHarvard University · US

Funding

Skeletal health in obesity and after bariatric surgeryK23DK093713 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI YU, ELAINE WEI-YIN · 2012 to 2016
$788k
Comparative and long-term effects of bariatric surgery on bone healthR03DK107869 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI YU, ELAINE WEI-YIN · 2016 to 2017
$157k
NIDDK NIH HHS K23 DK093713NIDDK NIH HHS R03 DK107869
6 · The paper itself

Abstract

The long-term consequences of bariatric surgery on fracture risk are unclear but are likely to vary by procedure type. In physiologic studies, Roux-en-Y gastric bypass (RYGB) and adjustable gastric banding (AGB) have differential effects on rates of bone loss. Therefore, our objective was to compare fracture risk in obese adults after RYGB and AGB procedures. Using claims data from a US commercial health plan, we analyzed rates of nonvertebral fractures within a propensity score-matched cohort (n = 15,032) of morbidly obese adults who received either RYGB or AGB surgery between 2005 and 2013. A total of 281 nonvertebral fractures occurred during a mean follow-up time of 2.3 ± 1.9 years. RYGB patients had an increased risk of nonvertebral fracture (hazard ratio [HR] = 1.43, 95% confidence interval [CI] 1.13-1.81) compared with AGB patients. In fracture site-specific analyses, RYGB patients had increased risk of fracture at the hip (HR = 1.54, 95% CI 1.03-2.30) and wrist (HR = 1.45, 95% CI 1.01-2.07). Nonvertebral fracture risk associated with RYGB manifested >2 years after surgery and increased in subsequent years, with the highest risk in the fifth year after surgery (HR = 3.91, 95% CI 1.58-9.64). In summary, RYGB is associated with a 43% increased risk of nonvertebral fracture compared with AGB, with risk increasing >2 years after surgery. Fracture risk should be considered in risk/benefit discussions of bariatric surgery, particularly among patients with high baseline risk of osteoporosis who are deciding between RYGB and AGB procedures. © 2017 American Society for Bone and Mineral Research.

Indexed as

AdultCohort StudiesFemaleFractures, BoneGastric BypassGastroplastyHumansIncidenceKaplan-Meier EstimateMalePropensity ScoreProportional Hazards ModelsRisk FactorsFRACTURE RISK ASSESSMENTGENERAL POPULATION STUDIESOSTEOPOROSIS

Identifiers

PMID28251687
PMCPMC5466471
OpenAlexW2592071604

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.