ArticleThe British journal of surgery2017
Impact of hepatobiliary service centralization on treatment and outcomes in patients with colorectal cancer and liver metastases.
Article in The British journal of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Locally advanced mid/low rectal cancer with synchronous resectable liver metastases: systematic review of the available strategies and outcome.Updates in surgery · 2024Pooled it
- Outcome quality standards for surgery of colorectal liver metastasis.Langenbeck's archives of surgery · 2020Pooled it
- A Multicenter Phase 2 Trial to Evaluate the Efficacy of mFOLFOX6 + Cetuximab as Induction Chemotherapy to Achieve R0 Surgical Resection for Advanced Colorectal Liver Metastases (NEXTO Trial).Annals of surgical oncology · 2020Trial
- Trends and Outcomes of the Liver-First Surgical Approach for Patients with Colorectal Cancer and Isolated Liver Metastases.Annals of surgical oncology · 2026Article
- Comprehensive management of synchronous colorectal liver metastases at a high-volume center: a propensity score-matched analysis.Updates in surgery · 2025Article
- The 'social gradient' in primary liver cancer in France: A national observational study.JHEP reports : innovation in hepatology · 2025Article
- What is the impact of hospital and surgeon volumes on outcomes in rectal cancer surgery?Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2023Article
- Practice patterns of hepatobiliary surgery within the military.Surgical endoscopy · 2023Article
- Association of Variation in US County-Level Rates of Liver Surgical Resection for Colorectal Liver Metastasis With Poverty Rates in 2010.JAMA network open · 2023Article
- Improvements over time for patients following liver trauma: A 17-year observational study.Frontiers in surgery · 2023Article
- Very Early Recurrence After Liver Resection for Colorectal Metastases: Incidence, Risk Factors, and Prognostic Impact.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- Liver-First Approach for Synchronous Colorectal Metastases: Analysis of 7360 Patients from the LiverMetSurvey Registry.Annals of surgical oncology · 2021Article
- National variation in pulmonary metastasectomy for colorectal cancer.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2021Article
- Multidisciplinary treatment for colorectal liver metastases in elderly patients.World journal of surgical oncology · 2020Article
- Predicting prognosis in colorectal liver metastases.Hepatobiliary surgery and nutrition · 2019Article
- Variation in the Use of Resection for Colorectal Cancer Liver Metastases.Annals of surgery · 2019Article
- Impact of cancer service centralisation on the radical treatment of men with high-risk and locally advanced prostate cancer: A national cross-sectional analysis in England.International journal of cancer · 2019Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCentralization of specialist surgical services can improve patient outcomes. The aim of this cohort study was to compare liver resection rates and survival in patients with primary colorectal cancer and synchronous metastases limited to the liver diagnosed at hepatobiliary surgical units (hubs) with those diagnosed at hospital Trusts without hepatobiliary services (spokes).
methodsThe study included patients from the National Bowel Cancer Audit diagnosed with primary colorectal cancer between 1 April 2010 and 31 March 2014 who underwent colorectal cancer resection in the English National Health Service. Patients were linked to Hospital Episode Statistics data to identify those with liver metastases and those who underwent liver resection. Multivariable random-effects logistic regression was used to estimate the odds ratio of liver resection by presence of specialist hepatobiliary services on site. Survival curves were estimated using the Kaplan-Meier method.
resultsOf 4547 patients, 1956 (43·0 per cent) underwent liver resection. The 1081 patients diagnosed at hubs were more likely to undergo liver resection (adjusted odds ratio 1·52, 95 per cent c.i. 1·20 to 1·91). Patients diagnosed at hubs had better median survival (30·6 months compared with 25·3 months for spokes; adjusted hazard ratio 0·83, 0·75 to 0·91). There was no difference in survival between hubs and spokes when the analysis was restricted to patients who had liver resection (P = 0·620) or those who did not undergo liver resection (P = 0·749).
conclusionPatients with colorectal cancer and synchronous metastases limited to the liver who are diagnosed at hospital Trusts with a hepatobiliary team on site are more likely to undergo liver resection and have better survival.
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