Evidence map›Paper›PMID 28251517›Full record

ArticleVirologica Sinica2017

A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China.

Rong Guo, Shu Shen, Yanfang Zhang, Junming Shi, Zhengyuan Su, Dan Liu, Jinliang Liu, Juan Yang, Qiguo Wang, Zhihong Hu and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Virologica Sinica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Rong GuoThe Center for Disease Control and Prevention of Xinjiang Uygur Autonomous' Region, Urumqi, Xinjiang, 830002, China.
Shu ShenState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Yanfang ZhangState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Junming ShiState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Zhengyuan SuState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Dan LiuSchool of Medicine, Wuhan University of Science and Technology, Wuhan, 430065, China.
Jinliang LiuState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Juan YangState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Qiguo WangThe Center for Disease Control and Prevention of Xinjiang Uygur Autonomous' Region, Urumqi, Xinjiang, 830002, China.
Zhihong HuThe Center for Disease Control and Prevention of Xinjiang Uygur Autonomous' Region, Urumqi, Xinjiang, 830002, China.
Yujiang ZhangThe Center for Disease Control and Prevention of Xinjiang Uygur Autonomous' Region, Urumqi, Xinjiang, 830002, China. xjsyzhang@163.com.
Fei DengState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Chinese Academy of Sciences · CNWuhan Institute of Virology · CNXinjiang Uygur Autonomous Region Disease Prevention and Control Center · CNWuhan University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world. Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China. Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China. A preliminary investigation of infection and antigens expression of CCHFV was performed in newborn mice. The target tissues for CCHFV replication in newborn mice were identified. The analysis of the phylogenetic relationships with other Chinese strains suggested that diverse genotypes of CCHFV have circulated in Xinjiang for years. These findings provide important insights into our understanding of CCHFV infection and evolution as well as disease prevention and control for local residents.

Indexed as

AnimalsAnimals, NewbornAntigens, ViralChinaCluster AnalysisGenotypeHemorrhagic Fever Virus, Crimean-CongoIxodidaeMice, Inbred BALB CPhylogenyRNA, ViralSequence Analysis, DNASequence HomologyViral TropismVirus ReplicationAntigens, ViralRNA, ViralCrimean-Congo hemorrhagic fever virus (CCHFV)genotypenewborn micephylogenetic analysis

Identifiers

PMID28251517
PMCPMC6598972
OpenAlexW2593946357

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.