ArticleEuropean journal of applied physiology2017
Effect of lifelong football training on the expression of muscle molecular markers involved in healthy longevity.
Article in European journal of applied physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis.Frontiers in public health · 2023Pooled it
- The Effects of Social Dance on Muscular Fitness and Longevity-Related Circulating Biomarkers in the Elderly.Journal of functional morphology and kinesiology · 2026Article
- The role of exercise in modulating NAD+ metabolic enzymes: mechanisms and health benefits.Frontiers in sports and active living · 2026Review
- Exercise's impact on lung cancer molecular mechanisms: a current overview.Frontiers in oncology · 2024Review
- Bone Health, Body Composition and Physiological Demands in 70-85-Year-Old Lifelong Male Football Players.Sports (Basel, Switzerland) · 2023Article
- Football training as a non-pharmacological treatment of the global aging population-A topical review.Frontiers in aging · 2023Review
- Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players.International journal of environmental research and public health · 2022Article
- Effects of Different Types of Chronic Training on Bioenergetic Profile and Reactive Oxygen Species Production in LHCN-M2 Human Myoblast Cells.International journal of molecular sciences · 2022Article
- Regular football training down-regulates miR-1303 muscle expression in veterans.European journal of applied physiology · 2021Article
- Football and team handball training postpone cellular aging in women.Scientific reports · 2021Article
- Insulin-Stimulated Muscle Glucose Uptake and Insulin Signaling in Lean and Obese Humans.The Journal of clinical endocrinology and metabolism · 2021Article
- Long-Term Recreational Football Training and Health in Aging.International journal of environmental research and public health · 2020Review
- Aerobic and resistance exercise training reverses age-dependent decline in NADPhysiological reports · 2019Article
- Slowing Down Ageing: The Role of Nutrients and Microbiota in Modulation of the Epigenome.Nutrients · 2019Review
- Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion.Frontiers in physiology · 2019Article
- Muscle health and performance in monozygotic twins with 30 years of discordant exercise habits.European journal of applied physiology · 2018Article
- Mechanisms and Measurement of Changes in Gene Expression.Biological research for nursing · 2018Article
- Regulatory Role of MicroRNAs in Muscle Atrophy during Exercise Intervention.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe investigated whether lifelong football training affects the expression of healthy longevity-related muscle molecular markers.
methodsBiopsies were collected from the vastus lateralis muscle of 10 lifelong football-trained men (68.2 ± 3.0 years) and of 10 active untrained healthy men (66.7 ± 1.3 years). Gene and protein expression was measured by RTqPCR on RNA and by western blotting on protein extracts from muscle biopsies, respectively.
resultsThe expression of AMPKα1/α2, NAMPT, TFAM and PGC1α, which are markers of oxidative metabolism, and MyHC β isoform expression was higher in the muscle of football-trained men vs untrained men. Also citrate synthase activity was higher in trained than in untrained men (109.3 ± 9.2 vs 75.1 ± 9.2 mU/mg). These findings were associated with a healthier body composition in trained than in untrained men [body weight: 78.2 ± 6.5 vs 91.2 ± 11.2 kg; body mass index BMI: 24.4 ± 1.6 vs 28.8 ± 4.0 kg m
conclusionsLifelong football training increases the expression of key markers involved in muscle oxidative metabolism, and in the DNA repair and senescence suppression pathways, thus providing the molecular basis for healthy longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.