Evidence map›Paper›PMID 28251396›Full record

ArticleEuropean journal of applied physiology2017

Polymorphisms in PTK2 are associated with skeletal muscle specific force: an independent replication study.

Georgina K Stebbings, A G Williams, C I Morse, S H Day

Open access · hybridAbstract read
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In one paragraph

Article in European journal of applied physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Georgina K StebbingsMMU Sports Genomics Laboratory, Department of Exercise and Sport Science, Manchester Metropolitan University, Crewe, UK. g.stebbings@mmu.ac.uk.
A G WilliamsMMU Sports Genomics Laboratory, Department of Exercise and Sport Science, Manchester Metropolitan University, Crewe, UK.
C I MorseMMU Sports Genomics Laboratory, Department of Exercise and Sport Science, Manchester Metropolitan University, Crewe, UK.
S H DayMMU Sports Genomics Laboratory, Department of Exercise and Sport Science, Manchester Metropolitan University, Crewe, UK.
Genomics (United Kingdom) · GBManchester Metropolitan University · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of the study was to investigate two single nucleotide polymorphisms (SNP) in PTK2 for associations with human muscle strength phenotypes in healthy men.

methodsMeasurement of maximal isometric voluntary knee extension (MVC

resultsGenotype frequencies for both SNPs were in Hardy-Weinberg equilibrium (X

conclusionsThese findings identify a genetic contribution to the inter-individual variability within muscle specific force and provides the first independent replication, in a larger Caucasian cohort, of an association between these PTK2 SNPs and muscle specific force, thus extending our understanding of the influence of genetic variation on the intrinsic strength of muscle.

Indexed as

Polymorphism, Single NucleotideAdolescentFocal Adhesion Kinase 1Gene FrequencyHeterozygoteHomozygoteHumansMaleMuscle, SkeletalMuscle StrengthPhenotypeYoung AdultFocal Adhesion Kinase 1PTK2 protein, humanFocal adhesion kinaseGenetic polymorphismLateral transmissionMuscle qualityProtein tyrosine kinase 2Vastus lateralis

Identifiers

PMID28251396
OpenAlexW2593296096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.