Evidence map›Paper›PMID 28251330›Full record

ArticleNeuroradiology2017

Oculo-auriculo-vertebral spectrum: going beyond the first and second pharyngeal arch involvement.

Brotto Davide, Manara Renzo, Ghiselli Sara, Lovo Elisa, Mardari Rodica, Toldo Irene, Castiglione Alessandro, Schifano Giovanni, Stritoni Valentina, Bovo Roberto and 2 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Benefits of bone conduction hearing aid in children with unilateral aural atresia.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2023
    Article
  3. Review
  4. Review
  5. OCULO-AURICULO-VERTEBRAL SPECTRUM ASSOCIATED WITH ABERRANT SUBCLAVIAN ARTERY IN AN INFANT WITH RECURRENT RESPIRATORY DISTRESS.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2021
    Article
  6. Oculoauriculovertebral spectrum and maxillary sinus volumes : CT-based comparative evaluation.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Brotto DavideDepartment of Neurosciences, Otorhinolaryngology Unit, University of Padova, Via Giustiniani 2, 35128, Padova, Italy. davidebrotto@hotmail.it.
Manara RenzoNeuroradiology, Sezione di Neuroscienze, University of Salerno, Salerno, Italy.
Ghiselli SaraDepartment of Neurosciences, Otorhinolaryngology Unit, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
Lovo ElisaDepartment of Neurosciences, Otorhinolaryngology Unit, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
Mardari RodicaNeuroradiology, University Hospital of Padova, Padova, Italy.
Toldo IrenePediatric Neurology Unit, Department of Woman's and Child's Health, University of Padova, Padova, Italy.
Castiglione AlessandroDepartment of Neurosciences, Otorhinolaryngology Unit, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
Schifano GiovanniDepartment of Neurosciences, Otorhinolaryngology Unit, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
Stritoni ValentinaTIPED, Department of Pediatrics, University of Padova, Padova, Italy.
Bovo RobertoDepartment of Neurosciences, Otorhinolaryngology Unit, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
Trevisi PatriziaDepartment of Neurosciences, Otorhinolaryngology Unit, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
Martini AlessandroDepartment of Neurosciences, Otorhinolaryngology Unit, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
University of Padua · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIntracranial vascular, bone, and brain abnormalities might be observed in oculo-auriculo-vertebral spectrum (OAVS) patients even though these structures do not derive embryologically from the first and second pharyngeal arches. This neuroimaging study investigated their type, frequency and phenotype correlations among OAVS patients.

methodsThirty-five OAVS patients (mean-age 4.8 ± 6.0 years; age range 0.3-30, 14 females) underwent head CT (all patients) and brain MRI (32 patients); 19 patients had a more severe phenotype (Goldenhar syndrome). Internal carotid artery hypoplasia/agenesia and abnormal course, brain abnormalities, internal acoustic canal stenosis/aplasia, cochlear-vestibular malformations, facial nerve bony canal anomalies, and oval window atresia were recorded.

resultsNine of 35 (26%) OAVS patients showed internal carotid artery anomalies; 18/32 (56%) had protean brain MRI abnormalities, ranging from tegmental cap anomaly to mild ventriculomegaly, which were associated with Goldenhar syndrome (p < 0.001) and concomitant cranial nerve abnormalities (p = 0.004); 11/35 (31%) disclosed cochlear-vestibular abnormalities including Michel deformity, common cavity, cochlear hypoplasia, and incomplete partition type-1 that were associated with Goldenhar syndrome (p = 0.01) and ipsilateral VIII cranial nerve abnormalities (p < 0.001); 16/35 (46%, 23 sides) presented facial nerve bony canal abnormalities that were associated with Goldenhar syndrome (p < 0.001) and ipsilateral VII cranial nerve (p < 0.001) and cochlear-vestibular (p < 0.001) abnormalities; and 23/31 (74%, 31 sides) showed oval window atresia, always with concomitant ossicular chain dysplasia.

conclusionsIntracranial vascular, bone, and brain abnormalities in OAVS patients are strikingly common and heterogeneous. As their detection might impact significantly on clinical and surgical management of affected patients, accurate neuroimaging investigations should be included in the diagnostic work-up of OAVS.

Indexed as

Abnormalities, MultipleAdolescentAdultChildChild, PreschoolFemaleGoldenhar SyndromeHumansInfantMagnetic Resonance ImagingMalePhenotypeTomography, X-Ray ComputedBrain abnormalitiesCarotid artery abnormalitiesGoldenhar syndromeInner ear abnormalitiesOculo-auriculo-vertebral spectrum

Identifiers

PMID28251330
OpenAlexW2593575833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.