Evidence map›Paper›PMID 28251277›Full record

SynthesisEuropean journal of clinical pharmacology2017

Hospital admissions due to adverse drug reactions in the elderly. A meta-analysis.

T J Oscanoa, F Lizaraso, Alfonso Carvajal

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05387096 (OPTImization of Medication by Transdisciplinary Assessment of Drug Treatment in Elderly Hospitalized Patients), which is not on this map. Cited by 182 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
182citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05387096 naunknown statusnot on this mapstarted 2023, after this paper: background citation

OPTImization of Medication by Transdisciplinary Assessment of Drug Treatment in Elderly Hospitalized Patients: Application of a Definitive Intervention by Physicians or Clinical Pharmacists

TypeinterventionalSponsorUniversity College CorkRan2023 to 2024Enrolled642ConditionsMultimorbidity, PolypharmacyArmsDefinitive multi-faceted intervention consisting of several components, Sham Intervention
3 · Its place in the literature

Who cites it

182 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  7. Drug-related deaths among inpatients: a meta-analysis.European journal of clinical pharmacology · 2022
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122 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

T J OscanoaDepartamento de Farmacología de la Facultad de Medicina de la Universidad Nacional Mayor de San Marcos, Lima District, Peru.
F LizarasoInstituto de Investigación de la Facultad de Medicina de la Universidad de San Martín de Porres, Calandrias, Peru.
Alfonso CarvajalCentro de Estudios sobre la Seguridad de los Medicamentos (CESME), Universidad de Valladolid, Valladolid, Spain. carvajal@ife.uva.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIt is currently admitted that adverse drug reactions (ADRs) account for a great burden of disease. Of particular concern are ADR-induced hospital admissions, particularly in the elderly; they receive most of the medications and they are the most prone to develop ADRs. Therefore, our aim was to carry out a study of ADR-induced hospital admissions focused on the elderly population.

methodsFor the purpose, a systematic review and meta-analysis was performed of those studies addressing ADR-induced hospital admissions in patients over 60 years of age. A computerized search of the literature was carried out in the main databases. The search spans from 1988 to 2015. A pooled prevalence figure was calculated with 95% CIs; heterogeneity was also explored.

resultsThe final number of selected articles was 42; all of them were published between January 1988 and August 2015. The overall average percentage of hospital admissions was 8.7% (95% CI, 7.6-9.8%). NSAIDs are one of the medication classes more frequently related to these admissions (percentages range from 2.3 to 33.3%). Inappropriate medication as a risk factor was studied in nine studies, four found a statistically significant relationship between those medications and hospital admissions.

conclusionsCirca one in ten hospital admissions of older patients are due to ADRs. A great burden of disease is due to a few and identifiable medication classes; in most of the cases, the reactions are well known and probably preventable. A sense of purpose and determination is needed by health authorities to face this problem. Doctors, on their part, should be aware when prescribing some specific identifiable medications to these patients. KEY POINTS: 1. One in ten hospital admissions in older patients are due to ADRs; NSAIDs are the medications the most related with these admissions, followed by other common medications used in patients of this age, such as beta-blockers. 2. A great burden of disease is due to medications that are intended to cure or alleviate disease; this burden of disease is not only painful for the patients but also costly. 3. Identified risk factors are particular medication classes and polymedication. In most of the cases, reactions are probably preventable.

Indexed as

Adverse Drug Reaction Reporting SystemsAgedDrug-Related Side Effects and Adverse ReactionsHospitalizationHumansInappropriate PrescribingMiddle AgedPatient AdmissionPolypharmacyRisk FactorsADRsElderly patientsHospital admissionsMeta-analysis

Identifiers

PMID28251277

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.