Evidence map›Paper›PMID 28251181›Full record

ArticlemSphere

Maternal Immunoreactivity to Herpes Simplex Virus 2 and Risk of Autism Spectrum Disorder in Male Offspring.

Milada Mahic, Siri Mjaaland, Hege Marie Bøvelstad, Nina Gunnes, Ezra Susser, Michaeline Bresnahan, Anne-Siri Øyen, Bruce Levin, Xiaoyu Che, Deborah Hirtz and 8 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Viruses and autism: A Bi-mutual cause and effect.World journal of virology · 2023
    Review
  10. Article
  11. Developmental Manipulation-Induced Changes in Cognitive Functioning.Current topics in behavioral neurosciences · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Microbiota and Microglia Interactions in ASD.Frontiers in immunology · 2021
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Milada MahicCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA; Norwegian Institute of Public Health, Oslo, Norway.
Siri MjaalandCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA; Norwegian Institute of Public Health, Oslo, Norway.
Hege Marie BøvelstadNorwegian Institute of Public Health, Oslo, Norway.
Nina GunnesNorwegian Institute of Public Health, Oslo, Norway.
Ezra SusserDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA; New York State Psychiatric Institute, Columbia University, New York, New York, USA.
Michaeline BresnahanDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA; New York State Psychiatric Institute, Columbia University, New York, New York, USA.
Anne-Siri ØyenNorwegian Institute of Public Health, Oslo, Norway; Nic Waals Institute, Lovisenberg Hospital, Oslo, Norway.
Bruce LevinDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA.
Xiaoyu CheCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA.
Deborah HirtzNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Ted Reichborn-KjennerudNorwegian Institute of Public Health, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Synnve SchjølbergNorwegian Institute of Public Health, Oslo, Norway.
Christine RothNorwegian Institute of Public Health, Oslo, Norway; Nic Waals Institute, Lovisenberg Hospital, Oslo, Norway.
Per MagnusNorwegian Institute of Public Health, Oslo, Norway.
Camilla StoltenbergNorwegian Institute of Public Health, Oslo, Norway; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Pål SurénNorwegian Institute of Public Health, Oslo, Norway.
Mady HornigCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
W Ian LipkinCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
Norwegian Institute of Public Health · NOColumbia University · USNew York Psychoanalytic Society and Institute · USNational Institutes of Health · USUniversity of Bergen · NO

Funding

Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
Infection, fever and immune signatures in an autism birth cohortR56NS086122 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HORNIG, MADY HORNIG, LIPKIN, W. IAN · 2014 to 2014
$789k
NINDS NIH HHS R56 NS086122NINDS NIH HHS U01 NS047537
6 · The paper itself

Abstract

Maternal infections during pregnancy are associated with risk of neurodevelopmental disorders, including autism spectrum disorders (ASDs). Proposed pathogenetic mechanisms include fetal infection, placental inflammation, and maternal cytokines or antibodies that cross the placenta. The Autism Birth Cohort comprises mothers, fathers, and offspring recruited in Norway in 1999 to 2008. Through questionnaire screening, referrals, and linkages to a national patient registry, 442 mothers of children with ASD were identified, and 464 frequency-matched controls were selected. Immunoglobulin G (IgG) antibodies to

Indexed as

autismbirth cohortherpes simplex virusinfectionprenatalserology

Identifiers

PMID28251181
PMCPMC5322345
OpenAlexW2590171645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.