ArticleInternational journal of ophthalmology2017
Light-emitting-diode induced retinal damage and its wavelength dependency
Article in International journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- The Effect of a Photochromic Contact Lens on Visual Function Indoors: A Randomized, Controlled Trial.Optometry and vision science : official publication of the American Academy of Optometry · 2020Trial
- Evaluating the impact of blue-filtering intraocular lenses on macular oxidative stress: A comparative analysis of 8-hydroxy-2'-deoxyguanosine levels in the retinal tissue of donor eyes.Indian journal of ophthalmology · 2026Article
- Can Persistent Blue Light Exposure Cause a Molecular Shift in the Vitreous of Rodents?Scientifica · 2026Article
- High-Fructose High-Fat Diet Renders the Retina More Susceptible to Blue Light Photodamage in Mice.Antioxidants (Basel, Switzerland) · 2025Article
- Photic Retinopathy: Diagnosis and Management of This Phototoxic Maculopathy.Life (Basel, Switzerland) · 2025Review
- Article
- Impact of LED exposure on contrast sensitivity and protective efficacy of blue-blocking lenses.International journal of ophthalmology · 2025Article
- Decrease of alpha-crystallin A by miR-325-3p in retinal cells under blue light exposure.Molecules and cells · 2024Article
- An Experimental Phototherapy Device for Studying the Effects of Blue Light on Patients with Raynaud's Phenomenon.Annals of biomedical engineering · 2024Article
- Light Pollution and Oxidative Stress: Effects on Retina and Human Health.Antioxidants (Basel, Switzerland) · 2024Review
- Influence of white-light-emitting diodes on primary visual cortex layer 5 pyramidal neurons (V1L5PNs) and remodeling by blue-light-blocking lenses.International ophthalmology · 2024Article
- Impact of light-emitting diodes on visual cortex layer 5 pyramidal neurons (V1-L5PNs)-A rodent study.Molecular vision · 2024Article
- Long-term blue light rearing does not affect in vivo retinal function in young rhesus monkeys.Documenta ophthalmologica. Advances in ophthalmology · 2023Article
- Photobiomodulation at molecular, cellular, and systemic levels.Lasers in medical science · 2023Review
- Determination of Correlated Color Temperature in Ex Vivo Porcine Eyes during Intraocular Illumination.Journal of clinical medicine · 2023Article
- More light components and less light damage on rats' eyes: evidence for the photobiomodulation and spectral opponency.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Article
- Blue Light Exposure: Ocular Hazards and Prevention-A Narrative Review.Ophthalmology and therapy · 2023Review
- Article
- Effect of Light Emitting Diodes (LED) Exposure on Vitreous Metabolites-Rodent Study.Metabolites · 2023Article
- Blue-Light-Blocking Lenses Ameliorate Structural Alterations in the Rodent Hippocampus.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine light-emitting-diode (LED)-induced retinal neuronal cell damage and its wavelength-driven pathogenic mechanisms.
methodsSprague-Dawley rats were exposed to blue LEDs (460 nm), green LEDs (530 nm), and red LEDs (620 nm). Electroretinography (ERG), Hematoxylin and eosin (H&E) staining, transmission electron microscopy (TEM), terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), and immunohistochemical (IHC) staining, Western blotting (WB) and the detection of superoxide anion (O
resultsERG results showed the blue LED group induced more functional damage than that of green or red LED groups. H&E staining, TUNEL, IHC, and TEM revealed apoptosis and necrosis of photoreceptors and RPE, which indicated blue LED also induced more photochemical injury. Free radical production and iron-related molecular marker expressions demonstrated that oxidative stress and iron-overload were associated with retinal injury. WB assays correspondingly showed that defense gene expression was up-regulated after the LED light exposure with a wavelength dependency.
conclusionThe study results indicate that LED blue-light exposure poses a great risk of retinal injury in awake, task-oriented rod-dominant animals. The wavelength-dependent effect should be considered carefully when switching to LED lighting applications.
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