ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2017
Rapid 3D Refractive-Index Imaging of Live Cells in Suspension without Labeling Using Dielectrophoretic Cell Rotation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 117 citations in OpenAlex.
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- Microfluidic-based electrically driven particle manipulation techniques for biomedical applications.RSC advances · 2025Review
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- Label-free spatiotemporal decoding of single-cell fate via acoustic driven 3D tomography.Materials today. Bio · 2024Article
- Recent Advances and Current Trends in Transmission Tomographic Diffraction Microscopy.Sensors (Basel, Switzerland) · 2024Review
- Bidirectional and Stepwise Rotation of Cells and Particles Using Induced Charge Electroosmosis Vortexes.Biosensors · 2024Article
- Real-time simultaneous refractive index and thickness mapping of sub-cellular biology at the diffraction limit.Communications biology · 2024Article
- 3D integral imaging of acoustically trapped objects.Scientific reports · 2024Article
- AI-driven projection tomography with multicore fibre-optic cell rotation.Nature communications · 2024Article
- Design and implementation of a lab-on-a-chip for assisted reproductive technologies.BioImpacts : BI · 2024Article
- Continuous microfluidic flow-through protocol for selective and image-activated electroporation of single cells.RSC advances · 2023Article
- Trapping of a Single Microparticle Using AC Dielectrophoresis Forces in a Microfluidic Chip.Micromachines · 2023Article
- Review
- Universal optothermal micro/nanoscale rotors.Science advances · 2022Article
- Dynamic Tomographic Phase Microscopy by Double Six-Pack Holography.ACS photonics · 2022Article
- Spatial light interference microscopy: principle and applications to biomedicine.Advances in optics and photonics · 2021Article
- Rapid computational cell-rotation around arbitrary axes in 3D with multi-core fiber.Biomedical optics express · 2021Article
- Sensitive label-free imaging of brain samples using FxClear-based tissue clearing technique.iScience · 2021Article
- Refractive Index Changes of Cells and Cellular Compartments Upon Paraformaldehyde Fixation Acquired by Tomographic Phase Microscopy.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major challenge in the field of optical imaging of live cells is achieving rapid, 3D, and noninvasive imaging of isolated cells without labeling. If successful, many clinical procedures involving analysis and sorting of cells drawn from body fluids, including blood, can be significantly improved. A new label-free tomographic interferometry approach is presented. This approach provides rapid capturing of the 3D refractive-index distribution of single cells in suspension. The cells flow in a microfluidic channel, are trapped, and then rapidly rotated by dielectrophoretic forces in a noninvasive and precise manner. Interferometric projections of the rotated cell are acquired and processed into the cellular 3D refractive-index map. Uniquely, this approach provides full (360°) coverage of the rotation angular range around any axis, and knowledge on the viewing angle. The experimental demonstrations presented include 3D, label-free imaging of cancer cells and three types of white blood cells. This approach is expected to be useful for label-free cell sorting, as well as for detection and monitoring of pathological conditions resulting in cellular morphology changes or occurrence of specific cell types in blood or other body fluids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.