Evidence map›Paper›PMID 28251010›Full record

ArticleCase reports in pediatrics2017

Neonatal Liver Failure and Congenital Cirrhosis due to Gestational Alloimmune Liver Disease: A Case Report and Literature Review.

Carolina Roos Mariano da Rocha, Renata Rostirola Guedes, Carlos Oscar Kieling, Marina Rossato Adami, Carlos Thadeu Schmidt Cerski, Sandra Maria Gonçalves Vieira

Open access · goldAbstract readCase Reports
In one paragraph

Article in Case reports in pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Carolina Roos Mariano da RochaMedical School, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.ORCID 0000-0001-8950-9345
Renata Rostirola GuedesHospital de Clínicas de Porto Alegre, Pediatric Gastroenterology Unit, Porto Alegre, RS, Brazil.
Carlos Oscar KielingHospital de Clínicas de Porto Alegre, Pediatric Gastroenterology Unit, Porto Alegre, RS, Brazil.
Marina Rossato AdamiHospital de Clínicas de Porto Alegre, Pediatric Gastroenterology Unit, Porto Alegre, RS, Brazil.
Carlos Thadeu Schmidt CerskiDepartment of Pathology, Hospital de Clínicas de Porto Alegre, Pathology Unit, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Sandra Maria Gonçalves VieiraDepartment of Pediatrics, Hospital de Clínicas de Porto Alegre, Pediatric Gastroenterology Unit, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.ORCID 0000-0002-9788-5428
Hospital de Clínicas de Porto Alegre · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal liver failure (NLF) is a major cause of neonatal morbidity and mortality, presenting as acute liver failure and/or congenital cirrhosis. Many affected patients show antenatal signs of fetal injury. There are several causes of NLF and early diagnosis is mandatory to elucidate the etiology and determine a specific treatment or the best management strategy. Gestational alloimmune liver disease associated with neonatal hemochromatosis (GALD-NH) is a rare but potentially treatable cause of NLF. It should be considered in any neonate with fetal signs of disease and postnatal signs of liver failure with no other identifiable causes. GALD-NH is often diagnosed late and patients are therefore referred late to specialized centers, delaying treatment. This case highlights the consequences of late diagnosis and treatment of GALD-NH and emphasizes the importance of a high grade of suspicion of this disease in order to refer the patient to a specialized center soon enough to perform the appropriate treatment.

Identifiers

PMID28251010
PMCPMC5303837
OpenAlexW2582726849

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.