Evidence map›Paper›PMID 28250967›Full record

ArticleBiomaterials research2017

Osteogenesis evaluation of duck's feet-derived collagen/hydroxyapatite sponges immersed in dexamethasone.

Yeon Ji Kook, Dae Hoon Lee, Jeong Eun Song, Nirmalya Tripathy, Yoo Shin Jeon, Ha Yan Jeon, Joaquim M Oliveira, Rui L Reis, Gilson Khang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yeon Ji KookDepartment of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer Fusion Research Center, Chonbuk National University, 567, Beackje-daero, Deokjin, Jeonju, 561-756 Republic of Korea.
Dae Hoon LeeDepartment of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer Fusion Research Center, Chonbuk National University, 567, Beackje-daero, Deokjin, Jeonju, 561-756 Republic of Korea.
Jeong Eun SongDepartment of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer Fusion Research Center, Chonbuk National University, 567, Beackje-daero, Deokjin, Jeonju, 561-756 Republic of Korea.
Nirmalya TripathyDepartment of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer Fusion Research Center, Chonbuk National University, 567, Beackje-daero, Deokjin, Jeonju, 561-756 Republic of Korea.
Yoo Shin JeonDepartment of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer Fusion Research Center, Chonbuk National University, 567, Beackje-daero, Deokjin, Jeonju, 561-756 Republic of Korea.
Ha Yan JeonDepartment of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer Fusion Research Center, Chonbuk National University, 567, Beackje-daero, Deokjin, Jeonju, 561-756 Republic of Korea.
Joaquim M Oliveira3B's Research Group -Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimaraes, Portugal.
Rui L Reis3B's Research Group -Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimaraes, Portugal.
Gilson KhangDepartment of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer Fusion Research Center, Chonbuk National University, 567, Beackje-daero, Deokjin, Jeonju, 561-756 Republic of Korea.
University of Minho · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to investigate the osteogenesis effects of DC and DC/HAp sponge immersed in without and with dexamethasone.

methodsThe experimental groups in this study were DC and DC/HAp sponge immersed in without dexamethasone (Dex(-)DC and Dex(-)-DC/HAp group) and with dexamethasone (Dex(+)-DC and Dex(+)-DC/HAp group). We characterized DC and DC/HAp sponge using compressive strength, scanning electron microscopy (SEM). Also, osteogenic differentiation of BMSCs on sponge (Dex(-)DC, Dex(-)-DC/HAp, Dex(+)-DC and Dex(+)-DC/HAp group) was assessed by SEM, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazoliumbromide (MTT) assay, alkaline phosphatase (ALP) activity assay and reverse transcription-PCR (RT-PCR).

resultsIn this study, we assessed osteogenic differentiation of BMSCs on Duck's feet-derived collagen (DC)/HAp sponge immersed with dexamethasone Dex(+)-DC/HAp. These results showed that Dex(+)-DC/HAp group increased cell proliferation and osteogenic differentiation of BMSCs during 28 days.

conclusionFrom these results, Dex(+)-DC/HAp can be envisioned as a potential biomaterial for bone regeneration applications.

Indexed as

Bone regenerationDexamethasoneDuck’s feet-derived collagenHydroxyapatiteOsteogenesisSponges

Identifiers

PMID28250967
PMCPMC5324229
OpenAlexW2589629694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.