Evidence map›Paper›PMID 28250913›Full record

ArticleGenome integrity2017

Biomarkers of Ionizing Radiation Exposure: A Multiparametric Approach.

Dimphy Zeegers, Shriram Venkatesan, Shu Wen Koh, Grace Kah Mun Low, Pallavee Srivastava, Neisha Sundaram, Swaminathan Sethu, Birendranath Banerjee, Manikandan Jayapal, Oleg Belyakov and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Genome integrity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Occupational Low-Dose Radiation Affects the Expression of Immune Checkpoint of Medical Radiologists.International journal of environmental research and public health · 2022
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Using telomeric chromosomal aberrations to evaluate clastogen-induced genomic instability in mammalian cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2020
    Review
  10. Article
  11. Article
  12. Antioxidants (Basel, Switzerland) · 2018
    Article
  13. Ionizing radiation exposure: hazards, prevention, and biomarker screening.Environmental science and pollution research international · 2018
    Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Dimphy ZeegersDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Shriram VenkatesanDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Shu Wen KohDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Grace Kah Mun LowDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Pallavee SrivastavaDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Neisha SundaramDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Swaminathan SethuDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, Karnataka, India.
Birendranath BanerjeeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India.
Manikandan JayapalDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; NanoString Technologies, Seattle, WA, USA.
Oleg BelyakovDivision of Human Health, International Atomic Energy Agency, Vienna, Austria.
Rajamanickam BaskarResearch Office, Sengkang Health, Alexandra Hospital, Singapore.
Adayabalam S BalajeeREAC/TS, Oak Ridge Institute for Science and Education, Oak Ridge Associated Universities, Oak Ridge TN, USA.
M Prakash HandeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Human Health, International Atomic Energy Agency, Vienna, Austria; Tembusu College, National University of Singapore, Singapore.
National University of Singapore · SGInternational Atomic Energy Agency · ATAlexandra Hospital · SGKIIT University · INOak Ridge Associated Universities · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humans are exposed to ionizing radiation not only through background radiation but also through the ubiquitous presence of devices and sources that generate radiation. With the expanded use of radiation in day-to-day life, the chances of accidents or misuse only increase. Therefore, a thorough understanding of the dynamic effects of radiation exposure on biological entities is necessary. The biological effects of radiation exposure on human cells depend on much variability such as level of exposure, dose rate, and the physiological state of the cells. During potential scenarios of a large-scale radiological event which results in mass casualties, dose estimates are essential to assign medical attention according to individual needs. Many attempts have been made to identify biomarkers which can be used for high throughput biodosimetry screening. In this study, we compare the results of different biodosimetry methods on the same irradiated cells to assess the suitability of current biomarkers and push forward the idea of employing a multiparametric approach to achieve an accurate dose and risk estimation.

Indexed as

dicentricsgene signaturesmicronucleimultiparametric approachradiation biodosimetrytranslocationsγH2AX

Identifiers

PMID28250913
PMCPMC5320786
OpenAlexW2581452879

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.