Evidence map›Paper›PMID 28250911›Full record

ArticleGenome integrity2017

Effects of Valproic Acid on Radiation-Induced Chromosomal Aberrations in Human Lymphocytes.

María Vittoria Di Tomaso, Eric Gregoire, Wilner Martínez-López

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome integrity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Alterations in histone acetylation following exposure toRadiation and environmental biophysics · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

María Vittoria Di TomasoClemente Estable Biological Research Institute, Montevideo, Uruguay; Laboratoire de Dosimétrie Biologique, Institut de Radiobiologie et de Sureté Nucléaire, Fontenay-Aux-Roses, France; Department of Genetics, Clemente Estable Biological Research Institute, Montevideo, Uruguay.
Eric GregoireLaboratoire de Dosimétrie Biologique, Institut de Radiobiologie et de Sureté Nucléaire, Fontenay-Aux-Roses, France.
Wilner Martínez-LópezClemente Estable Biological Research Institute, Montevideo, Uruguay; Epigenetics and Genomic Instability Laboratory, Clemente Estable Biological Research Institute, Montevideo, Uruguay.
Instituto de Investigaciones Biológicas Clemente Estable · UY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the most widely employed histone deacetylases inhibitors in the clinic is the valproic acid (VA), proving to have a good tolerance and low side effects on human health. VA induces changes in chromatin structure making DNA more susceptible to damage induction and influence DNA repair efficiency. VA is also proposed as a radiosensitizing agent. To know if VA is suitable to sensitize human lymphocytes γ-irradiation

Indexed as

Biological dosimetrychromosomal aberrationshistone acetylationhistone deacetylase inhibitorsionizing radiationvalproic acid

Identifiers

PMID28250911
PMCPMC5320781
OpenAlexW2581512186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.