ArticlePharmacognosy research
New Cytotoxic Cembranoid from Indonesian Soft Coral
Article in Pharmacognosy research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Marine Natural Products From Indonesia and Their Biosynthetic Origins: Part 1: Terpenoids and Meroterpenoids.Chemistry & biodiversity · 2026Review
- Cytotoxic Compounds from Alcyoniidae: An Overview of the Last 30 Years.Marine drugs · 2022Review
- Cembranoids of Soft Corals: Recent Updates and Their Biological Activities.Natural products and bioprospecting · 2021Review
- Marine Natural Products from Indonesian Waters.Marine drugs · 2019Review
- A Brief Review on New Naturally Occurring Cembranoid Diterpene Derivatives from the Soft Corals of the GeneraMolecules (Basel, Switzerland) · 2019Review
- Anti-Tumor Activity of Cembranoid-Type Diterpenes Isolated from Nicotiana tabacum L.Biomolecules · 2019Article
- Cytotoxic Effects of Sarcophyton sp. Soft Corals-Is There a Correlation to Their NMR Fingerprints?Marine drugs · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
context
aimsThis research aimed to characterize the cytotoxic compounds in dominant soft coral species ( SUBJECTS AND
methodsIsolation of cytotoxic compounds through ethanol extracts had been done with preparative high-performance liquid chromatography and bioassay-guided fractionation by MCF-7 (breast) cancer cell lines. The structures of each cytotoxic compounds were elucidated on the basis of mass and nuclear magnetic resonance spectroscopic studies.
resultsElucidation through all compounds found a new cembranoid, namely, 2-hydroxy-crassocolide E (1), alongside with 5 known cembranoids; sarcophytoxide (2), sarcrassin E (3), 3,7,11-cembreriene-2,15-diol (4), 11,12-epoxy-Sarcophytol A (5), and sarcophytol A (6). All of these cembranoids were showed to inhibit the growth of MCF-7 (breast) cancer, with 50% inhibition of tumor cell lines growth lower than 30 mg/L.
conclusionsResults of this study suggest that a soft coral species which dominate a reef area is a potential source for various bioactive compounds. SUMMARY: Elucidation of cytotoxic compounds from
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