Evidence map›Paper›PMID 28250618›Full record

ArticleJournal of global infectious diseases

Utility of Loop-mediated Isothermal Amplification Assay, Polymerase Chain Reaction, and ELISA for Diagnosis of Leptospirosis in South Indian Patients.

Mallika Sengupta, Abhilash Kundavaram Paul Prabhakar, Sowmya Satyendra, David Thambu, Ooriapadickal Cherian Abraham, Veeraraghavan Balaji, Hua-Wei Chen, Chien-Chung Chao, Wei-Mei Ching, John Antony Jude Prakash

Open access · goldAbstract read
In one paragraph

Article in Journal of global infectious diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Polymerase chain reaction and loop-mediated isothermal amplification targeting lic13162, lic20239, and lipL32 genes for leptospirosis diagnosis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mallika SenguptaDepartment of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
Abhilash Kundavaram Paul PrabhakarDepartment of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
Sowmya SatyendraDepartment of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
David ThambuDepartment of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
Ooriapadickal Cherian AbrahamDepartment of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
Veeraraghavan BalajiDepartment of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
Hua-Wei ChenViral and Rickettsial Diseases Department, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA.
Chien-Chung ChaoViral and Rickettsial Diseases Department, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA.
Wei-Mei ChingViral and Rickettsial Diseases Department, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA.
John Antony Jude PrakashDepartment of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
Christian Medical College & Hospital · INChristian Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeptospirosis is a zoonotic disease which requires laboratory diagnosis for confirmation. MATERIALS AND

methodsIn this study serum samples from adults with acute undifferentiated fever (duration ≤15 days) were tested for IgM antibodies to

resultsAmong the 150 sera tested, three were positive by PCR, LAMP and IgM ELISA/modified Faines' criteria, two by only PCR; seven only by LAMP assay and forty fulfilled modified Faine's criteria (illness clinically compatible and IgM ELISA positive for leptospirosis). Clinical correlation revealed renal compromise, low platelet count and severe jaundice were significantly related to leptospirosis (

conclusionThis study suggests that LAMP assay could be useful for diagnosis of leptospirosis during the 1

Indexed as

DiagnosisIgM ELISAleptospirosisloop-mediated isothermal amplificationpolymerase chain reactionserum

Identifiers

PMID28250618
PMCPMC5330041
OpenAlexW2535177207

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.