ArticleNature materials2017
The microstructure and micromechanics of the tendon-bone insertion.
Article in Nature materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
155 citing papers in PubMed, 1 synthesis or guideline pooled it, 387 citations in OpenAlex.
- 3D-printed scaffold-based strategies for enthesis regeneration: a systematic review of the literature.Frontiers in bioengineering and biotechnology · 2026Pooled it
- Injectable Zein-Based Photothermal Composite Hydrogel Enhances Osteoporotic Tendon-Bone Healing.Small methods · 2026Article
- The developing tendon and enthesis are hypoxic and rely on hypoxia-inducible factor 1a during postnatal development.Development (Cambridge, England) · 2026Article
- BiomimeticBioactive materials · 2026Article
- A Collagen-based Scaffold Supports Tendon-to-bone Healing After Rotator Cuff Repair: An Integrated Translational Study.Advanced healthcare materials · 2026Article
- Translational Progress and Clinical Challenges in Bioengineered Bone and Joint Repair.Biomedicines · 2026Review
- Microengineered Gradient Hydrogels for Mechanobiology.Advanced healthcare materials · 2026Review
- Multicellular microtissues from fused ligament- and bone-cell spheroids relevant to enthesis repair.Materials today. Bio · 2026Article
- Biomimetic double-layered electrospun nanofibrous scaffold with mussel adhesive protein coating and TGF-β3 encapsulation for enhanced tendon-bone healing in rotator cuff tears.Materials today. Bio · 2026Article
- Senomorphic Small Extracellular Vesicles Delivered by a Tissue-Adhesive α-Lipoic-Acid Hydrogel Enable Immuno-Rejuvenation for Bone-Tendon Interface Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ZEB1 maintains mitochondrial fission and macrophage efferocytosis by restraining MFN2, thereby limiting inflammation and improving tendon‑bone healing.International journal of molecular medicine · 2026Article
- Highly bio-adapted hydrogels for tendon-bone interface regeneration: Natural healing inspiration, design strategies, and biomedical potential.Bioactive materials · 2026Review
- Visualizing the Achilles Tendon Enthesis: Translational Insights from 7-Tesla MR Microscopy and Histology.Diagnostics (Basel, Switzerland) · 2026Article
- Identification of a new population of TnnBone research · 2026Article
- Functional anatomy of entheses and enthesis organs: A celebration of Professor Mike Benjamin's contribution to enthesis biology.Journal of anatomy · 2026Review
- Collagen organisation in the fibrous joint capsules in the digits of the human hand.Journal of anatomy · 2026Review
- From physical modalities to energy-responsive biomaterials: Current strategies and challenges in tendon-to-bone healing.Bioactive materials · 2026Review
- The Role of Phagocytic Cells in the Achilles Tendon.International journal of molecular sciences · 2026Review
- Functionally Graded Surfaces and Materials: From Fabrication to Biomedical Applications.Chemical reviews · 2026Review
- Collagen-elastin microstructural network and its mechanical implications in the anterior cruciate ligament: A feasibility study.Journal of orthopaedic surgery and research · 2026Article
95 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The exceptional mechanical properties of the load-bearing connection of tendon to bone rely on an intricate interplay of its biomolecular composition, microstructure and micromechanics. Here we identify that the Achilles tendon-bone insertion is characterized by an interface region of ∼500 μm with a distinct fibre organization and biomolecular composition. Within this region, we identify a heterogeneous mechanical response by micromechanical testing coupled with multiscale confocal microscopy. This leads to localized strains that can be larger than the remotely applied strain. The subset of fibres that sustain the majority of loading in the interface area changes with the angle of force application. Proteomic analysis detects enrichment of 22 proteins in the interfacial region that are predominantly involved in cartilage and skeletal development as well as proteoglycan metabolism. The presented mechanisms mark a guideline for further biomimetic strategies to rationally design hard-soft interfaces.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.