ArticleNature immunology2017
THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 80 citations in OpenAlex.
- Structural and Biochemical Analysis of the CABIT1 Domain of THEMIS.bioRxiv : the preprint server for biology · 2026Article
- Structural and mechanistic insights into the constitutive Themis-Grb2 complex in T cell signalling.Nature communications · 2026Article
- THEMIS attenuates MASH by suppressing disease-associated hepatocyte induction and hepatocyte senescence in mice.The Journal of clinical investigation · 2026Article
- MYC-induced USP10 stabilizes SOX4 to promote thymocyte proliferation and leukemia onset in mice.Nature communications · 2026Article
- The role of Themis in development of type 2 diabetes.Research square · 2025Article
- ZDHHC21-driven S-palmitoylation of Themis regulates the function of T cells and maintains homeostatic balance.Cell communication and signaling : CCS · 2025Article
- Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation.Nature immunology · 2025Article
- Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development.The Journal of experimental medicine · 2024Review
- A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice.The Journal of allergy and clinical immunology · 2024Article
- THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation.Cellular and molecular life sciences : CMLS · 2024Article
- Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks.Immunity · 2024Article
- THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development.Nature structural & molecular biology · 2024Article
- Themis controls T cell activation, effector functions, and metabolism of peripheral CD8Life science alliance · 2023Article
- A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection.iScience · 2023Article
- A mutation inbioRxiv : the preprint server for biology · 2023Article
- GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1.The Journal of experimental medicine · 2023Article
- THEMIS increases TCR signaling in CD4Science signaling · 2023Article
- Themis suppresses the effector function of CD8Cellular & molecular immunology · 2023Article
- Treatment with Exogenously Added Catalase Alters CD8 T Cell Memory Differentiation and Function.Advanced biology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Seeyoung ChoiSection on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Claude WarzechaSection on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Ekaterina ZvezdovaSection on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Jan LeeSection on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Jérémy ArgentyCentre de Physiopathologie de Toulouse Purpan, Toulouse, France.
Renaud LesourneCentre de Physiopathologie de Toulouse Purpan, Toulouse, France.
L AravindNational Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
Paul E LoveSection on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USCentre de Physiopathologie de Toulouse-Purpan · FRNational Institutes of Health · USUnited States National Library of Medicine · USUniversité Toulouse III - Paul Sabatier · FR
Funding
Genes and signals controlling mammalian hematopoiesis.ZIAHD001803 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LOVE, PAUL E · 2009 to 2025
$36.9MSignals Regulating T Cell DevelopmentZ01HD001803 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LOVE, PAUL E · 1994 to 2008
$2.2MIntramural NIH HHS Z01 HD001803Intramural NIH HHS Z99 HD999999Intramural NIH HHS ZIA HD001803
Abstract
THEMIS, a T cell-specific protein with high expression in CD4
Indexed as
Signal TransductionAnimalsCell DifferentiationCell LineClonal Selection, Antigen-MediatedGene DeletionHumansIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutOxidation-ReductionProtein BindingProtein Interaction Domains and MotifsProtein Tyrosine Phosphatase, Non-Receptor Type 6Reactive Oxygen SpeciesReceptors, Antigen, T-CellIntracellular Signaling Peptides and ProteinsProtein Tyrosine Phosphatase, Non-Receptor Type 6Reactive Oxygen SpeciesReceptors, Antigen, T-Cellthymocyte-expressed molecule involved in selection, human
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.