ArticleJournal of musculoskeletal & neuronal interactions2017
Long-term wheel-running can prevent deterioration of bone properties in diabetes mellitus model rats.
Article in Journal of musculoskeletal & neuronal interactions, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Expert consensus statement for basic research of animal exercise intervention studies in chronic disease prevention and treatment: A joint position paper of the Exercise Science branch of the Biophysical Society of China and the Metabolism and Genetics branch of the Genetics Society of China.Journal of sport and health science · 2025Article
- A Review of Animal Models for Studying Bone Health in Type-2 Diabetes Mellitus (T2DM) and Obesity.International journal of molecular sciences · 2024Review
- Prevention of bone deterioration by whole-body vibration in a rat model of pre-type 2 diabetes.Journal of musculoskeletal & neuronal interactions · 2023Article
- Resistant dextrin protects against pathological bone loss in ovariectomized rats and inhibits RANKL-induced osteoclastogenesis.Histology and histopathology · 2022Article
- Effects of teriparatide and low-intensity aerobic exercise on osteopenia in type 2 diabetes mellitus rats.Journal of bone and mineral metabolism · 2022Article
- The effects on type 2 diabetes mellitus mouse femoral bone achieved by anti-osteoporosis exercise interventions.Frontiers in endocrinology · 2022Article
- Long-term wheel-running prevents reduction of grip strength in type 2 diabetic rats.Physiological reports · 2021Article
- Bone Autophagy: A Potential Way of Exercise-Mediated Meg3/P62/Runx2 Pathway to Regulate Bone Formation in T2DM Mice.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Impact of long-lasting spontaneous physical activity on bone morphogenetic protein 4 in the heart and tibia in murine model of heart failure.Physiological reports · 2020Article
- Vaspin antagonizes high fat-induced bone loss in rats and promotes osteoblastic differentiation in primary rat osteoblasts through Smad-Runx2 signaling pathway.Nutrition & metabolism · 2020Article
- Bone marrow adipose amount influences vertebral bone strength.Experimental and therapeutic medicine · 2019Article
- Upward running is more beneficial than level surface or downslope running in reverting tibia bone degeneration in ovariectomized rats.Journal of musculoskeletal & neuronal interactions · 2018Article
- High-fat/high-sucrose diet results in higher bone mass in aged rats.Bone reports · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this study was to examine the effects of long-term wheel-running on tibia bone properties in T2DM Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
methodsTen five-week-old male OLETF rats were used as experimental animals and 5 Long-Evans Tokushima Otsuka (LETO) rats as controls. Half of OLETF rats performed daily voluntary wheel-running for 17 months (OLETF-EXE), while neither the remainder of OLETF nor LETO rats had exercise. At the end of experiment, in addition to serum biochemical and bone formation/resorption marker analyses, bone mass, trabecular bone microarchitecture and cortical bone geometry were analyzed in left tibia, and bone mechanical strength of right tibia was measured.
resultsTibia bone mass, trabecular bone microarchitecture, cortical bone geometry and bone mechanical strength deteriorated in diabetic OLETF rats. However, such deterioration was obviously attenuated in OLETF-EXE rats, which maintained normal levels of blood glucose, HbA1c and blood urea nitrogen.
conclusionsDaily wheel-running could prevent the deterioration of bone properties in OLETF rats. This would be induced mainly by suppressing the development of T2DM. Regular physical exercise may be a potent strategy for preventing not only the development of diabetes but also the deterioration of bone properties in patients with chronic T2DM.
Indexed as
Identifiers
28250247PMC5383771W2965733701What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.