Evidence map›Paper›PMID 28250155›Full record

ArticleJournal of neurophysiology2017

Reflex wind-up in early chronic spinal injury: plasticity of motor outputs.

Michael D Johnson, Alain Frigon, Marie-France Hurteau, Charlette Cain, C J Heckman

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Michael D JohnsonDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; m-johnson16@northwestern.edu.
Alain FrigonDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Marie-France HurteauDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Charlette CainCenter for Comparative Medicine, Northwestern University, Chicago, Illinois; and.
C J HeckmanDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Northwestern University · USUniversité de Sherbrooke · CA

Funding

Mechanisms of Distorted Inputs in Chronic Spinal InjuryR01NS089313 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HECKMAN, CHARLES · 2014 to 2018
$1.7M
NINDS NIH HHS R01 NS089313
6 · The paper itself

Abstract

In this study we evaluate temporal summation (wind-up) of reflexes in select distal and proximal hindlimb muscles in response to repeated stimuli of the distal tibial or superficial peroneal nerves in cats 1 mo after complete spinal transection. This report is a continuation of our previous paper on reflex wind-up in the intact and acutely spinalized cat. To evaluate reflex wind-up in both studies, we recorded electromyographic signals from the following left hindlimb muscles: lateral gastrocnemius (LG), tibialis anterior (TA), semitendinosus (ST), and sartorius (Srt), in response to 10 electrical pulses to the tibial or superficial peroneal nerves. Two distinct components of the reflex responses were considered, a short-latency compound action potential (CAP) and a longer duration bout of sustained activity (SA). These two response types were shown to be differentially modified by acute spinal injury in our previous work (Frigon A, Johnson MD, Heckman CJ.

Indexed as

Evoked Potentials, MotorNeuronal PlasticityReflexAnimalsCatsMuscle, SkeletalSpinal Cord Injuriesmotoneuronreflexspinal cord injurywind-up

Identifiers

PMID28250155
PMCPMC5434480
OpenAlexW2591682032

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.