ArticleJournal of neurophysiology2017
Systems-based analysis of dendritic nonlinearities reveals temporal feature extraction in mouse L5 cortical neurons.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Impaired dendritic spike generation in the Fragile X prefrontal cortex is due to loss of dendritic sodium channels.The Journal of physiology · 2023Article
- Input rate encoding and gain control in dendrites of neocortical pyramidal neurons.Cell reports · 2022Article
- Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons.Neuron · 2021Article
- Active dendrites enable strong but sparse inputs to determine orientation selectivity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Effects ofJournal of neurophysiology · 2021Article
- GABAFrontiers in cellular neuroscience · 2021Article
- Article
- Intrinsic Mechanisms of Frequency Selectivity in the Proximal Dendrites of CA1 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Specialized Subpopulations of Deep-Layer Pyramidal Neurons in the Neocortex: Bridging Cellular Properties to Functional Consequences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Differential polarization of cortical pyramidal neuron dendrites through weak extracellular fields.PLoS computational biology · 2018Article
- Theta-frequency selectivity in the somatic spike-triggered average of rat hippocampal pyramidal neurons is dependent on HCN channels.Journal of neurophysiology · 2017Article
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Authors and funding
4 authors.
Funding
Abstract
What do dendritic nonlinearities tell a neuron about signals injected into the dendrite? Linear and nonlinear dendritic components affect how time-varying inputs are transformed into action potentials (APs), but the relative contribution of each component is unclear. We developed a novel systems-identification approach to isolate the nonlinear response of layer 5 pyramidal neuron dendrites in mouse prefrontal cortex in response to dendritic current injections. We then quantified the nonlinear component and its effect on the soma, using functional models composed of linear filters and static nonlinearities. Both noise and waveform current injections revealed linear and nonlinear components in the dendritic response. The nonlinear component consisted of fast Na
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