ArticleJournal of neurophysiology2017
mTOR regulates peripheral nerve response to tensile strain.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The impact of eccentric muscle contractions on peripheral nerve integrity.European journal of applied physiology · 2025Pooled it
- The Effect of Conduit Length on Offloading Nerve Repairs Through Strain-Shielding: A Cadaveric Biomechanical Study.Journal of hand surgery global online · 2026Article
- Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons.Advanced healthcare materials · 2025Article
- Article
- The role of mechanics in axonal stability and development.Seminars in cell & developmental biology · 2023Review
- Rapamycin-filgrastim combination therapy ameliorates portal hypertension-induced splenomegaly: Role of β actin and S100A9 proteins modulation.Iranian journal of basic medical sciences · 2022Article
- Clinical potential of tension-lengthening strategies during nerve repair.Neural regeneration research · 2022Article
- Mechanotransduction assays for neural regeneration strategies: A focus on glial cells.APL bioengineering · 2021Review
- Effect of Electrical and Electromechanical Stimulation on PC12 Cell Proliferation and Axon Outgrowth.Frontiers in bioengineering and biotechnology · 2021Article
- Axonal cytomechanics in neuronal development.Journal of biosciences · 2020Review
- Mechanical stimulation of Schwann cells promote peripheral nerve regeneration via extracellular vesicle-mediated transfer of microRNA 23b-3p.Theranostics · 2020Article
- Redistribution of nerve strain enables end-to-end repair under tension without inhibiting nerve regeneration.Neural regeneration research · 2019Article
- Theory of Bowstring Disease: Diagnosis and Treatment Bowstring Disease.Orthopaedic surgery · 2019Review
- A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment.Cell death and differentiation · 2018Article
- Influence of Phosphatidylinositol-3-Kinase/Protein Kinase B-Mammalian Target of Rapamycin Signaling Pathway on the Neuropathic Pain Complicated by Nucleoside Reverse Transcriptase Inhibitors for the Treatment of HIV Infection.Chinese medical journal · 2018Article
- Microtopographical cues promote peripheral nerve regeneration via transient mTORC2 activation.Acta biomaterialia · 2017Article
- Influence of Mechanical Stimuli on Schwann Cell Biology.Frontiers in cellular neuroscience · 2017Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
While excessive tensile strain can be detrimental to nerve function, strain can be a positive regulator of neuronal outgrowth. We used an in vivo rat model of sciatic nerve strain to investigate signaling mechanisms underlying peripheral nerve response to deformation. Nerves were deformed by 11% and did not demonstrate deficits in compound action potential latency or amplitude during or after 6 h of strain. As revealed by Western blotting, application of strain resulted in significant upregulation of mammalian target of rapamycin (mTOR) and S6 signaling in nerves, increased myelin basic protein (MBP) and β-actin levels, and increased phosphorylation of neurofilament subunit H (NF-H) compared with unstrained (sham) contralateral nerves (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.