Evidence map›Paper›PMID 28250124›Full record

ArticleJournal of virology2017

Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice.

Jorma Hinkula, Stéphanie Devignot, Sara Åkerström, Helen Karlberg, Eva Wattrang, Sándor Bereczky, Mehrdad Mousavi-Jazi, Christian Risinger, Gunnel Lindegren, Caroline Vernersson and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 102 citations in OpenAlex.

  1. Review
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  7. In Vitro Evaluation of Bunyavirus T Cell Immunity.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
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  12. Review
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  17. Review
  18. Article
  19. Review
  20. Crimean-Congo haemorrhagic fever virus.Nature reviews. Microbiology · 2023
    Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 5 countries.

Jorma HinkulaDepartment of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Stéphanie DevignotInstitute for Virology, Philipps University Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-0618-5611
Sara ÅkerströmNational Veterinary Institute, Uppsala, Sweden.
Helen KarlbergFolkhälsomyndigheten, Stockholm, Sweden.
Eva WattrangNational Veterinary Institute, Uppsala, Sweden.
Sándor BereczkyFolkhälsomyndigheten, Stockholm, Sweden.
Mehrdad Mousavi-JaziFolkhälsomyndigheten, Stockholm, Sweden.
Christian RisingerDepartment of Chemistry, University of Copenhagen, Frederiksberg, Denmark.
Gunnel LindegrenFolkhälsomyndigheten, Stockholm, Sweden.
Caroline VernerssonNational Veterinary Institute, Uppsala, Sweden.
Janusz PaweskaCentre for Emerging and Zoonotic Diseases, National Institute for Communicable Diseases, National Health Laboratory Service, Sandringham, South Africa.
Petrus Jansen van VurenCentre for Emerging and Zoonotic Diseases, National Institute for Communicable Diseases, National Health Laboratory Service, Sandringham, South Africa.
Ola BlixtDepartment of Chemistry, University of Copenhagen, Frederiksberg, Denmark.
Alejandro BrunCentro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, Spain.
Friedemann WeberInstitute for Virology, Philipps University Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0001-9737-337X
Ali MirazimiFolkhälsomyndigheten, Stockholm, Sweden Ali.Mirazimi@ki.se.
Public Health Agency of Sweden · SESwedish Veterinary Agency · SENational Health Laboratory Service · ZAPhilipps University of Marburg · DEUniversity of Copenhagen · DKInstituto Nacional de Investigación y Tecnología Agraria y Alimentaria · ESLinköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crimean-Congo hemorrhagic fever virus (CCHFV) is a bunyavirus causing severe hemorrhagic fever disease in humans, with high mortality rates. The requirement of a high-containment laboratory and the lack of an animal model hampered the study of the immune response and protection of vaccine candidates. Using the recently developed interferon alpha receptor knockout (IFNAR

Indexed as

AnimalsAntibodies, NeutralizingCapsid ProteinsDisease Models, AnimalEpitopes, B-LymphocyteHemorrhagic Fever, CrimeanHemorrhagic Fever Virus, Crimean-CongoHumansImmunity, CellularImmunizationImmunogenicity, VaccineInterferon-alphaMiceMice, KnockoutPlasmidsTh1 CellsAntibodies, NeutralizingCapsid ProteinsEpitopes, B-LymphocyteInterferon-alphaVaccines, DNAVaccines, Virus-Like ParticleViral Envelope ProteinsCrimean-Congo hemorrhagic fever virusDNA vaccinesneutralizing antibodiesTh1/Th2 responsesVLP

Identifiers

PMID28250124
PMCPMC5411611
OpenAlexW2592335950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.