Evidence map›Paper›PMID 28250053›Full record

ArticleJournal of the American Society of Nephrology : JASN2017

Two-Photon Intravital Fluorescence Lifetime Imaging of the Kidney Reveals Cell-Type Specific Metabolic Signatures.

Takashi Hato, Seth Winfree, Richard Day, Ruben M Sandoval, Bruce A Molitoris, Mervin C Yoder, Roger C Wiggins, Yi Zheng, Kenneth W Dunn, Pierre C Dagher

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
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  4. The Intricacies of Renal Phosphate Reabsorption-An Overview.International journal of molecular sciences · 2024
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  16. Metabolic mechanisms of acute proximal tubular injury.Pflugers Archiv : European journal of physiology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Takashi HatoDepartments of Medicine, thato@iu.edu pdaghe2@iupui.edu.
Seth WinfreeDepartments of Medicine.
Richard DayCellular and Integrative Physiology, and.
Ruben M SandovalDepartments of Medicine.
Bruce A MolitorisDepartments of Medicine.
Mervin C YoderPediatrics, Indiana University, Indianapolis, Indiana.
Roger C WigginsDepartment of Medicine, University of Michigan, Ann Arbor, Michigan; and.
Yi ZhengDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Kenneth W DunnDepartments of Medicine.
Pierre C DagherDepartments of Medicine, thato@iu.edu pdaghe2@iupui.edu.
Richard L. Roudebush VA Medical Center · USCincinnati Children's Hospital Medical Center · USIndiana University – Purdue University Indianapolis · USLaboratoire d’immunologie intégrative du cancer · FRUniversity of Michigan–Ann Arbor · US

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
PROBE DELIVERY COREP30DK079312 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI ASHKAR, TAREK MAURICE · 2007 to 2021
$17.1M
TUBULE CELL REGENERATION AND DIFFERENTIATIONP50DK039255 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WIGGINS, ROGER CHARLES · 1987 to 2007
$7.3M
The Glomerular PodocyteR01DK046073 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WIGGINS, ROGER CHARLES · 1993 to 2015
$4.7M
Endotoxin preconditioning as a model to uncover protective pathways in sepsis-induced renal injury.R01DK107623 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Pierre C Dagher · 2016 to 2026
$4.4M
Proximal Tubule Albumin Transport in Disease States.R01DK091623 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI MOLITORIS, BRUCE A · 2011 to 2021
$4.3M
Indiana Clinical and Translational Sciences InstituteKL2TR001106 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$3.2M
Modifying kidney injury through p53 signaling.R01DK099345 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DAGHER, PIERRE C, SUTTON, TIMOTHY ALAN · 2014 to 2017
$1.4M
Modulating purine metabolism to treat kidney injury in sepsis.K08DK113223 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI HATO, TAKASHI · 2017 to 2021
$757k
Podocyte Markers in Human Glomerular DiseasesR01DK102643 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WIGGINS, ROGER CHARLES · 2015 to 2017
$698k
Protective pathways in sepsis-induced renal injuryI01BX002901 · VA · RLR VA MEDICAL CENTER · PI Takashi Hato · 2016 to 2026
–
BLRD VA I01 BX002901NCATS NIH HHS KL2 TR001106NCATS NIH HHS UL1 TR001108NIDDK NIH HHS K08 DK113223NIDDK NIH HHS P30 DK079312NIDDK NIH HHS P30 DK097512NIDDK NIH HHS P50 DK039255NIDDK NIH HHS R01 DK046073NIDDK NIH HHS R01 DK091623NIDDK NIH HHS R01 DK099345NIDDK NIH HHS R01 DK102643NIDDK NIH HHS R01 DK107623
6 · The paper itself

Abstract

In the live animal, tissue autofluorescence arises from a number of biologically important metabolites, such as the reduced form of nicotinamide adenine dinucleotide. Because autofluorescence changes with metabolic state, it can be harnessed as a label-free imaging tool with which to study metabolism

Indexed as

Intravital MicroscopyMicroscopy, Fluorescence, MultiphotonAnimalsKidneyMaleMiceMice, Inbred C57BLendotheliummetabolismpodocytetubules

Identifiers

PMID28250053
PMCPMC5533239
OpenAlexW2594792468

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.