Trial reportThe bone & joint journal2017
Five-year follow-up results of the PROFHER trial comparing operative and non-operative treatment of adults with a displaced fracture of the proximal humerus.
Trial report in The bone & joint journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04623346 (Orthopaedic Conservative Treatment in the Time of Covid-19 Pandemic), which is not on this map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Orthopaedic Conservative Treatment in the Time of Covid-19 Pandemic
Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Interventions for treating proximal humeral fractures in adults.The Cochrane database of systematic reviews · 2022Pooled it
- Use of different devices for surgical treatment of proximal humerus fractures in adults: a systematic review.Acta bio-medica : Atenei Parmensis · 2021Pooled it
- Pooled it
- Percutaneous fixation with Kirschner wires versus volar locking-plate fixation in adults with dorsally displaced fracture of distal radius: five-year follow-up of a randomized controlled trial.The bone & joint journal · 2019Trial
- Longer hospital stay but similar one-year mortality and readmission after combined proximal humerus and proximal femur fragility fractures: a Propensity-Score-Matched Cohort Study.Archives of orthopaedic and trauma surgery · 2026Article
- Imaging-based assessment of fracture stability does not reliably predict outcomes in patients with two-part proximal humeral fractures and may lead to unnecessary surgeries.EFORT open reviews · 2026Review
- Review
- Randomized controlled trials investigating proximal humerus fractures lack consensus in inclusion criteria.JSES reviews, reports, and techniques · 2025Article
- Proximal humerus fractures in the elderly: is there (still) a role for plate osteosynthesis?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Review
- Value-adaptive clinical trial designs for efficient delivery of publicly funded trials - a discussion of methods, case studies, opportunities and challenges.BMC medical research methodology · 2025Article
- Non-operative versus reverse shoulder arthroplasty for the treatment of 3- or 4-part proximal humeral fractures: A systematic review and meta-analysis.Journal of clinical orthopaedics and trauma · 2025Review
- Plate osteosynthesis versus non-surgical treatment in displaced proximal humerus fractures-long term functional outcome and quality of life.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- Human-centered design of a health recommender system for orthopaedic shoulder treatment.BMC medical informatics and decision making · 2025Article
- Clinical Outcome and Quality of Life after Modular Reverse Total Shoulder Arthroplasty in Comparison with Joint-Preserving Locking Plate Osteosynthesis in Aged Patients: A Retrospective Comparison Study.Orthopaedic surgery · 2025Article
- Percutaneous Pinning for Proximal Humerus Fractures: Insights From a Five-Year Retrospective Study.Cureus · 2024Article
- Open reduction and internal fixation of the proximal humerus with femoral head allograft augmentation "the French fry technique".JSES reviews, reports, and techniques · 2024Article
- Intramedullary nailing of proximal humerus fractures does not achieve superior functional results to non-operative treatment in the long term.Archives of orthopaedic and trauma surgery · 2024Article
- Human-centered Design of a Health Recommender System for Orthopaedic Shoulder Treatment.Research square · 2024Article
- Conservative treatment of 3- and 4-part proximal humeral fractures: Can poor outcomes be predicted?European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Immobilization Period for the Non-Operative Treatment of Proximal Humerus Fractures: Systematic Review and Meta-Analysis.The archives of bone and joint surgery · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
aimsThe PROximal Fracture of the Humerus Evaluation by Randomisation (PROFHER) randomised clinical trial compared the operative and non-operative treatment of adults with a displaced fracture of the proximal humerus involving the surgical neck. The aim of this study was to determine the long-term treatment effects beyond the two-year follow-up. PATIENTS AND
methodsOf the original 250 trial participants, 176 consented to extended follow-up and were sent postal questionnaires at three, four and five years after recruitment to the trial. The Oxford Shoulder Score (OSS; the primary outcome), EuroQol 5D-3L (EQ-5D-3L), and any recent shoulder operations and fracture data were collected. Statistical and economic analyses, consistent with those of the main trial were applied.
resultsOSS data were available for 164, 155 and 149 participants at three, four and five years, respectively. There were no statistically or clinically significant differences between operative and non-operative treatment at each follow-up point. No participant had secondary shoulder surgery for a new complication. Analyses of EQ-5D-3L data showed no significant between-group differences in quality of life over time.
conclusionThese results confirm that the main findings of the PROFHER trial over two years are unchanged at five years. Cite this article:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.