Evidence map›Paper›PMID 28249845›Full record

Trial reportJournal of the American Heart Association2017

Efficacy of Prophylactic Dexmedetomidine in Preventing Postoperative Junctional Ectopic Tachycardia After Pediatric Cardiac Surgery.

Doaa Mohamed El Amrousy, Nagat S Elshmaa, Mohamed El-Kashlan, Samir Hassan, Mohamed Elsanosy, Nahed Hablas, Shimaa Elrifaey, Wael El-Feky

Retracted Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. It is linked to trial NCT04234906 (Multicenter Study for the Prevention of Post-Operative Cardiac Arrhythmias), which is not on this map. Cited by 17 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 5 pooled it
27.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04234906 phase4unknown statusnot on this mapstarted 2023, after this paper: background citation

Multicenter Study for the Prevention of Post-Operative Cardiac Arrhythmias

TypeinterventionalSponsorJeffrey MoakRan2023 to 2023Enrolled870ConditionsCardiac, Dysrhythmia, Postoperative, Congenital Heart SurgeryArmsDexmedetomidine, Magnesium Sulfate, Amiodarone, Procainamide
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 123 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Article
  8. Observational
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Doaa Mohamed El AmrousyPediatric Department, Tanta University Hospital, Tanta, Egypt doaamoha@yahoo.com.
Nagat S ElshmaaDepartment of Anesthesia & Surgical ICU, Faculty of Medicine, Tanta University, Tanta, Egypt.
Mohamed El-KashlanDepartment of Anesthesia & Surgical ICU, Faculty of Medicine, Tanta University, Tanta, Egypt.
Samir HassanPediatric Department, Tanta University Hospital, Tanta, Egypt.
Mohamed ElsanosyPediatric Department, Tanta University Hospital, Tanta, Egypt.
Nahed HablasPediatric Department, Tanta University Hospital, Tanta, Egypt.
Shimaa ElrifaeyPediatric Department, Tanta University Hospital, Tanta, Egypt.
Wael El-FekyCardiothoracic Surgery Department, Tanta University Hospital, Tanta, Egypt.
Tanta University Hospital · EGTanta University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative junctional ectopic tachycardia is one of the most serious arrhythmias that occur after pediatric cardiac surgery, difficult to treat and better to be prevented. Our aim was to assess the efficacy of prophylactic dexmedetomidine in preventing junctional ectopic tachycardia after pediatric cardiac surgery. METHODS AND

resultsA prospective controlled study was carried out on 90 children who underwent elective cardiac surgery for congenital heart diseases. Patients were randomized into 2 groups. Group I (dexmedetomidine group): 60 patients received dexmedetomidine; Group II (Placebo group): 30 patients received the same amount of normal saline intravenously. The primary outcome was the incidence of postoperative junctional ectopic tachycardia. Secondary outcomes included bradycardia, hypotension, vasoactive inotropic score, ventilation time, pediatric cardiac care unit stay, length of hospital stay, and perioperative mortality. The incidence of junctional ectopic tachycardia was significantly reduced in the dexmedetomidine group (3.3%) compared with the placebo group (16.7%) with

conclusionProphylactic use of dexmedetomidine is associated with significantly decreased incidence of postoperative junctional ectopic tachycardia in children after congenital heart surgery without significant side effects.

Indexed as

Adrenergic alpha-2 Receptor AgonistsCardiac Surgical ProceduresDexmedetomidineDose-Response Relationship, DrugElectrocardiographyFemaleHeart Defects, CongenitalHeart RateHumansInfantInfusions, IntravenousMalePostoperative ComplicationsProspective StudiesTachycardia, Ectopic JunctionalTreatment OutcomeAdrenergic alpha-2 Receptor AgonistsDexmedetomidinechildrendexmedetomidinepostoperative junctional ectopic tachycardia

Identifiers

PMID28249845
PMCPMC5524013
OpenAlexW2591576856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.