Evidence map›Paper›PMID 28249842›Full record

ArticleClinical and vaccine immunology : CVI2017

Tuberculous Lymphadenitis Is Associated with Enhanced Baseline and Antigen-Specific Induction of Type 1 and Type 17 Cytokines and Reduced Interleukin-1β (IL-1β) and IL-18 at the Site of Infection.

Gokul Raj Kathamuthu, Kadar Moideen, Dhanaraj Baskaran, Vaithilingam V Banurekha, Dina Nair, Gomathi Sekar, Rathinam Sridhar, Bharathi Vidyajayanthi, Ganeshan Gajendraraj, Dinesh Kumar Parandhaman and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Compartment-specific inflammation in tuberculous lymphadenitis: a case-control study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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  7. Serum lymphocytes and cytokines: diagnostic value and influence on the immune status in patients with pulmonary tuberculosis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2023
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  12. Tuberculous lymphadenitis is associated with altered levels of circulating angiogenic factors.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2018
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Gokul Raj KathamuthuNational Institutes of Health-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, India.
Kadar MoideenNational Institutes of Health-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, India.
Dhanaraj BaskaranNational Institute for Research in Tuberculosis, Chennai, India.
Vaithilingam V BanurekhaNational Institute for Research in Tuberculosis, Chennai, India.
Dina NairNational Institute for Research in Tuberculosis, Chennai, India.
Gomathi SekarNational Institute for Research in Tuberculosis, Chennai, India.
Rathinam SridharGovernment Stanley Medical Hospital, Chennai, India.
Bharathi VidyajayanthiGovernment Kilpauk Medical Hospital, Chennai, India.
Ganeshan GajendrarajGovernment General Hospital, Chennai, India.
Dinesh Kumar ParandhamanNational Institute for Research in Tuberculosis, Chennai, India.
Alena SrinivasanNational Institute for Research in Tuberculosis, Chennai, India.
Subash BabuNational Institutes of Health-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, India sbabu@mail.nih.gov.
National Institute of Research in Tuberculosis · INGovernment General Hospital · INGovernment Kilpauk Medical College · INNational Institute of Allergy and Infectious Diseases · USStanley Medical College · IN

Funding

India International Center for Excellence in ResearchZIAAI001065 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NUTMAN, THOMAS · 2009 to 2025
$19.0M
Wellcome Trust
6 · The paper itself

Abstract

Tuberculous lymphadenitis (TBL) is characterized by an expansion of Th1 and Th17 cells with altered serum levels of proinflammatory cytokines. However, the cytokine profile at the site of infection, i.e., the affected lymph nodes, has not been examined in detail. To estimate the baseline and mycobacterial antigen-stimulated concentrations of type 1, type 17, and other proinflammatory cytokines in patients with TBL (

Indexed as

AdolescentAdultCytokinesFemaleHumansMaleMiddle AgedTh17 CellsTh1 CellsTuberculosis, Lymph NodeYoung AdultCytokinescytokineslymphadenitistuberculosis

Identifiers

PMID28249842
PMCPMC5424238
OpenAlexW2593137680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.