ArticlePsychological medicine2017
Baseline demographics, clinical features and predictors of conversion among 200 individuals in a longitudinal prospective psychosis-risk cohort.
Article in Psychological medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 6 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Network Meta-Analysis Indicates Superior Effects of Omega-3 Polyunsaturated Fatty Acids in Preventing the Transition to Psychosis in Individuals at Clinical High-Risk.The international journal of neuropsychopharmacology · 2024Pooled it
- The temporal dynamics of transition to psychosis in individuals at clinical high-risk (CHR-P) shows negative prognostic effects of baseline antipsychotic exposure: a meta-analysis.Translational psychiatry · 2023Pooled it
- Association between formal thought disorders, neurocognition and functioning in the early stages of psychosis: a systematic review of the last half-century studies.European archives of psychiatry and clinical neuroscience · 2022Pooled it
- The associations between migrant status and ethnicity and the identification of individuals at ultra-high risk for psychosis and transition to psychosis: a systematic review.Social psychiatry and psychiatric epidemiology · 2021Pooled it
- Negative Prognostic Effect of Baseline Antipsychotic Exposure in Clinical High Risk for Psychosis (CHR-P): Is Pre-Test Risk Enrichment the Hidden Culprit?The international journal of neuropsychopharmacology · 2021Pooled it
- Cannabis use in individuals at clinical high-risk for psychosis: a comprehensive review.Social psychiatry and psychiatric epidemiology · 2020Pooled it
- Elevated defeatist performance beliefs predict state increases in negative symptoms in daily life in clinical high-risk for psychosis youth: implications for mobile health treatments.European archives of psychiatry and clinical neuroscience · 2026Article
- Article
- Association Between Social and Role Functioning and Transition to Psychosis in the North American Prodrome Longitudinal Study Consortium.Schizophrenia bulletin · 2026Article
- Loss of regional theta differentiation in TMS-EEG response marks network dysfunction in psychosis risk.Translational psychiatry · 2026Article
- Explainable artificial intelligence (XAI) in schizophrenia: enhancing transparency in clinical decision-making.Frontiers in systems biology · 2026Review
- Do Obsessive-Compulsive Symptoms Increase the Risk of Developing Psychosis? A Systematic Review and Meta-analysis.Schizophrenia bulletin open · 2026Article
- Shift in sex and age of individuals at a clinical high risk (CHR) for psychosis: relation to differences in recruitment methods and effect on sample characteristics.Schizophrenia (Heidelberg, Germany) · 2025Article
- Cognition as a predictor of social network size and early communication in clinically high risk for psychosis individuals.Schizophrenia research. Cognition · 2025Review
- Subgroups of Clinical High Risk for Psychosis Based on Baseline Antipsychotic Exposure: Clinical and Outcome Comparisons Across a 2-Year Follow-up Period.Schizophrenia bulletin · 2025Article
- The relationship between COMT, proline, and negative symptoms in clinical high risk and recent psychosis onset.Translational psychiatry · 2024Article
- The Impact of Prolonged Duration of Untreated Illness on Clinical Correlates in Chronic Schizophrenia: Exploring the Relationship With Suicide Risk.Psychiatry investigation · 2024Article
- Article
- Predicting new onset thought disorder in early adolescence with optimized deep learning implicates environmental-putamen interactions.medRxiv : the preprint server for health sciences · 2023Article
- Symptoms of Attenuated Psychosis Syndrome in Relatives of Clinical High-Risk Youth: Preliminary Evidence.Schizophrenia bulletin · 2023Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundDSM-5 proposes an Attenuated Psychosis Syndrome (APS) for further investigation, based upon the Attenuated Positive Symptom Syndrome (APSS) in the Structured Interview for Psychosis-Risk Syndromes (SIPS). SIPS Unusual Thought Content, Disorganized Communication and Total Disorganization scores predicted progression to psychosis in a 2015 NAPLS-2 Consortium report. We sought to independently replicate this in a large single-site high-risk cohort, and identify baseline demographic and clinical predictors beyond current APS/APSS criteria.
methodWe prospectively studied 200 participants meeting criteria for both the SIPS APSS and DSM-5 APS. SIPS scores, demographics, family history of psychosis, DSM Axis-I diagnoses, schizotypy, and social and role functioning were assessed at baseline, with follow-up every 3 months for 2 years.
resultsThe conversion rate was 30% (n = 60), or 37.7% excluding participants who were followed under 2 years. This rate was stable across time. Conversion time averaged 7.97 months for 60% who developed schizophrenia and 15.68 for other psychoses. Mean conversion age was 20.3 for males and 23.5 for females. Attenuated odd ideas and thought disorder appear to be the positive symptoms which best predict psychosis in a logistic regression. Total negative symptom score, Asian/Pacific Islander and Black/African-American race were also predictive. As no Axis-I diagnosis or schizotypy predicted conversion, the APS is supported as a distinct syndrome. In addition, cannabis use disorder did not increase risk of conversion to psychosis.
conclusionsNAPLS SIPS findings were replicated while controlling for clinical and demographic factors, strongly supporting the validity of the SIPS APSS and DSM-5 APS diagnosis.
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