ArticleBMC medical genetics2017
Identification of somatic mutations using whole-exome sequencing in Korean patients with acute myeloid leukemia.
Article in BMC medical genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Ontologies and Knowledge Graphs in Oncology Research.Cancers · 2022Review
- Data on somatic mutations obtained by whole exome sequencing of FFPE tissue samples from Russian patients with prostate cancer.Data in brief · 2019Article
- Epidemiology and biology of relapse after stem cell transplantation.Bone marrow transplantation · 2018Review
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
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Abstract
backgroundAcute myeloid leukemia (AML) is a biologically and clinically heterogeneous cancer of the bone marrow that is characterized by the rapid growth of abnormal myeloid cells.
methodsWe performed a mutational analysis to identify AML somatic mutations using the whole-exome sequencing data of 36 tumor-normal sample pairs from Korean patients with de novo AML. We explored the functional impact of the genes identified in the mutational analyses through an integrated Gene Ontology (GO) and pathway analysis.
resultsA total of 11 genes, including NEFH (p = 6.27 × 10
conclusionsMorphological AML subtypes may in part reflect subtype specific patterns of genomic alterations. Following validation, future studies to evaluate the usefulness of these genes in genetic testing for the early diagnosis and prognostic prediction of AML patients would be worthwhile.
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