Evidence map›Paper›PMID 28249118›Full record

ArticleAmerican journal of respiratory and critical care medicine2017

Antenatal Determinants of Bronchopulmonary Dysplasia and Late Respiratory Disease in Preterm Infants.

Lindsey A Morrow, Brandie D Wagner, David A Ingram, Brenda B Poindexter, Kurt Schibler, C Michael Cotten, John Dagle, Marci K Sontag, Peter M Mourani, Steven H Abman

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 4 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 4 syntheses or guidelines pooled it, 190 citations in OpenAlex.

  1. Pooled it
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  8. Article
  9. Titrating cumulative neonatal hyperoxia in mice to model bronchopulmonary dysplasia severities.American journal of respiratory cell and molecular biology · 2026
    Article
  10. Article
  11. Review
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  13. Article
  14. Maternal smoking and CC-16: implications for lung development and COPD across the lifespan.American journal of respiratory and critical care medicine · 2026
    Article
  15. Article
  16. Long-term pulmonary outcomes in BPD throughout the life-course.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  17. Article
  18. Review
  19. Review
  20. Prenatal Cannabis and Tobacco: Studies in Animal Models.Advances in experimental medicine and biology · 2026
    Review

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Lindsey A Morrow1 Pediatric Heart Lung Center, Department of Pediatrics, Children's Hospital Colorado.
Brandie D Wagner1 Pediatric Heart Lung Center, Department of Pediatrics, Children's Hospital Colorado.
David A Ingram3 Section of Neonatal-Perinatal Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.
Brenda B Poindexter3 Section of Neonatal-Perinatal Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.
Kurt Schibler4 Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
C Michael Cotten5 Department of Neonatology, Duke University Medical School, Durham, North Carolina; and.
John Dagle6 Division of Neonatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Marci K Sontag7 Department of Epidemiology.
Peter M Mourani1 Pediatric Heart Lung Center, Department of Pediatrics, Children's Hospital Colorado.
Steven H Abman1 Pediatric Heart Lung Center, Department of Pediatrics, Children's Hospital Colorado.
Children's Hospital Colorado · USCincinnati Children's Hospital Medical Center · USDuke University · USIndiana University School of MedicineNational Institute of Epidemiology · INUniversity of Iowa · US

Funding

Role of VEGF in Perinatal Pulmonary HypertensionR01HL068702 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ABMAN, STEVEN HERBERT, SHEPHERD, DOUGLAS · 2001 to 2021
$6.7M
Genetic Basis for Impaired Angiogenic Signaling in BPDR01HL085703 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ABMAN, STEVEN HERBERT · 2008 to 2012
$3.3M
NHLBI NIH HHS R01 HL068702NHLBI NIH HHS R01 HL085703
6 · The paper itself

Abstract

rationaleMechanisms contributing to chronic lung disease after preterm birth are incompletely understood.

objectivesTo identify antenatal risk factors associated with increased risk for bronchopulmonary dysplasia (BPD) and respiratory disease during early childhood after preterm birth, we performed a prospective, longitudinal study of 587 preterm infants with gestational age less than 34 weeks and birth weights between 500 and 1,250 g.

methodsData collected included perinatal information and assessments during the neonatal intensive care unit admission and longitudinal follow-up by questionnaire until 2 years of age. MEASUREMENTS AND MAIN

resultsAfter adjusting for covariates, we found that maternal smoking prior to preterm birth increased the odds of having an infant with BPD by twofold (P = 0.02). Maternal smoking was associated with prolonged mechanical ventilation and respiratory support during the neonatal intensive care unit admission. Preexisting hypertension was associated with a twofold (P = 0.04) increase in odds for BPD. Lower gestational age and birth weight z-scores were associated with BPD. Preterm infants who were exposed to maternal smoking had higher rates of late respiratory disease during childhood. Twenty-two percent of infants diagnosed with BPD and 34% of preterm infants without BPD had no clinical signs of late respiratory disease during early childhood.

conclusionsWe conclude that maternal smoking and hypertension increase the odds for developing BPD after preterm birth, and that maternal smoking is strongly associated with increased odds for late respiratory morbidities during early childhood. These findings suggest that in addition to the BPD diagnosis at 36 weeks, other factors modulate late respiratory outcomes during childhood. We speculate that measures to reduce maternal smoking not only will lower the risk for preterm birth but also will improve late respiratory morbidities after preterm birth.

Indexed as

Infant, PrematureBronchopulmonary DysplasiaCausalityColoradoFemaleFollow-Up StudiesHumansHypertensionInfant, NewbornLongitudinal StudiesMaleMothersPregnancyPrenatal Exposure Delayed EffectsProspective StudiesRespiratory Distress Syndrome, Newbornbronchopulmonary dysplasiahypertensive disorders of pregnancymaternal smokingpreeclampsiaprematurity

Identifiers

PMID28249118
PMCPMC5549867
OpenAlexW2592988251

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.