Evidence map›Paper›PMID 28249028›Full record

Trial reportPloS one2017

Heart rate variability during hemodialysis is an indicator for long-term vascular access survival in uremic patients.

Ya-Ting Huang, Yu-Ming Chang, I-Ling Chen, Chuan-Lan Yang, Show-Chin Leu, Hung-Li Su, Jsun-Liang Kao, Shih-Ching Tsai, Rong-Na Jhen, Woung-Ru Tang and 2 more

Erratum issuedOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ya-Ting HuangGraduate Institute of Clinical medical sciences, Chang Gung University, Taoyuan City, Taiwan (R.O.C.).
Yu-Ming ChangDivision of Nephrology, Department of Internal Medicine, Saint Mary's hospital Luodong, Yilan, Taiwan (R.O.C.).
I-Ling ChenDepartment of Nursing, Saint Mary's hospital Luodong, Yilan, Taiwan (R.O.C.).
Chuan-Lan YangDepartment of Nursing, Saint Mary's hospital Luodong, Yilan, Taiwan (R.O.C.).
Show-Chin LeuDepartment of Nursing, Saint Mary's hospital Luodong, Yilan, Taiwan (R.O.C.).
Hung-Li SuDepartment of Nursing, Saint Mary's hospital Luodong, Yilan, Taiwan (R.O.C.).
Jsun-Liang KaoDivision of Nephrology, Department of Internal Medicine, Saint Mary's hospital Luodong, Yilan, Taiwan (R.O.C.).
Shih-Ching TsaiDivision of Nephrology, Department of Internal Medicine, Saint Mary's hospital Luodong, Yilan, Taiwan (R.O.C.).
Rong-Na JhenDivision of Nephrology, Department of Internal Medicine, Saint Mary's hospital Luodong, Yilan, Taiwan (R.O.C.).
Woung-Ru TangGraduate Institute of Nursing, Chang Gung University, Taoyuan City, Taiwan (R.O.C.).
Chih-Chung ShiaoDivision of Nephrology, Department of Internal Medicine, Saint Mary's hospital Luodong, Yilan, Taiwan (R.O.C.).ORCID http://orcid.org/0000-0003-2220-7574
SMHRG (Saint Mary’s Hospital Research Group on Geriatrics)
Saint Mary's Hospital Luodong · TWChang Gung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVascular access (VA) is the lifeline of hemodialysis patients. Although the autonomic nervous system might be associated with VA failure (VAF), it has never been addressed in previous studies. This study aimed to evaluate the predictive values of the heart rate variability (HRV) indices for long-term VA outcomes.

methodsThis retrospective study was conducted using a prospectively established cohort enrolling 175 adult chronic hemodialysis patients (100 women, mean age 65.1 ± 12.9 years) from June 2010 to August 2010. Each participant received a series of HRV measurements at enrollment. After a 60-month follow-up period, we retrospectively reviewed all events and therapeutic procedures of the VAs which existed at the enrollment and during the follow-up period.

resultsDuring the 60-month follow-up period, 37 (26.8%) had VAF but 138 (73.2%) didn't. The values of most HRV indices were statistically increased during hemodialysis since initiation in the non-VAF group, but not in the VAF group. Among all participants, the independent indicators for VAF included higher normalized high-frequency (nHF) activity [hazard ratio (HR) 1.04, p = 0.005], lower low-frequency/high-frequency (LF/HF) ratio (HR 0.80, p = 0.015), experience of urokinase therapy (HR 11.18, p = 0.002), percutaneous transluminal angioplasty (HR 2.88, p = 0.003) and surgical thrombectomy (HR 2.36, p = 0.035), as well as higher baseline serum creatinine (HR 1.07, p = 0.027) and potassium level (HR 1.58, p = 0.037). In subgroup analysis, a lower sympathetic activity indicated by lower LF/HF ratio was an independent indicator for VAF (HR 0.61, p = 0.03) for tunneled cuffed catheter, but conversely played a protective role against VAF (HR 1.27, p = 0.002) for arteriovenous fistula.

conclusionsHRV is a useful tool for predicting long-term VAF among hemodialysis patients.

Indexed as

Heart RateRenal DialysisUremiaVascular Access DevicesAgedDisease-Free SurvivalFemaleFollow-Up StudiesHumansMaleMiddle AgedSurvival Rate

Identifiers

PMID28249028
PMCPMC5331988
OpenAlexW2594726598

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.