Evidence map›Paper›PMID 28249002›Full record

Trial reportPloS one2017

Role of the APOE polymorphism in carotid and lower limb revascularization: A prospective study from Southern Italy.

Sandra Mastroianno, Giuseppe Di Stolfo, Davide Seripa, Michele Antonio Pacilli, Giulia Paroni, Carlo Coli, Maria Urbano, Carmela d'Arienzo, Carolina Gravina, Domenico Rosario Potenza and 3 more

Open access · goldAbstract readClinical TrialComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Sandra MastroiannoCardiology Unit, Cardiological and Vascular Department, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Giuseppe Di StolfoCardiology Unit, Cardiological and Vascular Department, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.ORCID http://orcid.org/0000-0003-1758-7138
Davide SeripaComplex Structure of Geriatrics, Medical Sciences Department, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Michele Antonio PacilliCardiology Unit, Cardiological and Vascular Department, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Giulia ParoniComplex Structure of Geriatrics, Medical Sciences Department, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Carlo ColiCardiology Unit, Cardiological and Vascular Department, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Maria UrbanoComplex Structure of Geriatrics, Medical Sciences Department, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Carmela d'ArienzoCardiology Unit, Cardiological and Vascular Department, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Carolina GravinaComplex Structure of Geriatrics, Medical Sciences Department, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Domenico Rosario PotenzaCardiology Unit, Cardiological and Vascular Department, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Giovanni De LucaCardiology Unit, Cardiological and Vascular Department, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Antonio GrecoComplex Structure of Geriatrics, Medical Sciences Department, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Aldo RussoCardiology Unit, Cardiological and Vascular Department, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Casa Sollievo della Sofferenza · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtherosclerosis is a complex multifactorial disease and the apolipoprotein E (APOE) polymorphism has been associated to vascular complications of atherosclerosis.

objectivesTo investigate the relationship between the APOE genotypes and advanced peripheral vascular disease. MATERIALS AND

methods258 consecutive patients (201 males and 57 females, mean age 70.83 ± 7.89 years) with severe PVD were enrolled in a 42-months longitudinal study (mean 31.65 ± 21.11 months) for major adverse cardiovascular events. At follow-up genotypes of the APOE polymorphism were investigated in blinded fashion.

resultsAs compared with ε3/ε3, in ε4-carriers a significant higher incidence of major adverse cardiovascular events (35.58% vs. 20.79%; p = 0.025) and total peripheral revascularization (22.64% vs. 5.06%; p < 0.001) was observed. Prospective analysis, showed that ε4-carriers have an increased hazard ratio for major adverse cardiovascular events (adjusted HR 1.829, 95% CI 1.017-3.287; p = 0.044) and total peripheral revascularization (adjusted HR = 5.916, 95% CI 2.405-14.554, p <0.001).

conclusionsThe ε4 allele seems to be risk factor for major adverse cardiovascular events, and in particular for total peripheral revascularization in patients with advanced atherosclerotic vascular disease.

Indexed as

AllelesAtherosclerosisCarotid ArteriesGenotypePolymorphism, GeneticAgedApolipoproteins EFemaleFollow-Up StudiesHumansIncidenceItalyLower ExtremityMaleMiddle AgedProspective StudiesApolipoproteins E

Identifiers

PMID28249002
PMCPMC5332070
OpenAlexW2593998525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.