ArticleScientific data2017
Systematic high-content genome-wide RNAi screens of endothelial cell migration and morphology.
Article in Scientific data, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Engineering etiology-aligned in vitro models of human vessels.Microsystems & nanoengineering · 2026Review
- Efficient Bayesian inference for mechanistic modelling with high-throughput data.PLoS computational biology · 2022Article
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- Issues of origin, morphology and clinical significance of tumor microvessels in gastric cancer.World journal of gastroenterology · 2021Review
- From imaging a single cell to implementing precision medicine: an exciting new era.Emerging topics in life sciences · 2021Article
- Adverse Effect of Circadian Rhythm Disorder on Reparative Angiogenesis in Hind Limb Ischemia.Journal of the American Heart Association · 2021Article
- Systematic analysis of migration factors by MigExpress identifies essential cell migration control genes in non-small cell lung cancer.Molecular oncology · 2021Article
- Genome-wide RNAi screen for genes regulating glycolytic response to vemurafenib in BRAFScientific data · 2020Article
- Amino Acid Transporters as Targets for Cancer Therapy: Why, Where, When, and How.International journal of molecular sciences · 2020Review
- Overexpression of lncRNA MT1JP Mediates Apoptosis and Migration of Hepatocellular Carcinoma Cells by Regulating miR-24-3p.Cancer management and research · 2020Article
- From observing to predicting single-cell structure and function with high-throughput/high-content microscopy.Essays in biochemistry · 2019Review
- New artery of knowledge: 3D models of angiogenesis.Vascular biology (Bristol, England) · 2019Review
- The Interplay Between Lymphatic Vessels and Chemokines.Frontiers in immunology · 2019Review
- Consensus guidelines for the use and interpretation of angiogenesis assays.Angiogenesis · 2018Review
- Emerging Roles for VEGF-D in Human Disease.Biomolecules · 2018Review
- A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity.Scientific reports · 2017Article
- Knocking down the obstacles to functional genomics data sharing.Scientific data · 2017Article
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many cell types undergo migration during embryogenesis and disease. Endothelial cells line blood vessels and lymphatics, which migrate during development as part of angiogenesis, lymphangiogenesis and other types of vessel remodelling. These processes are also important in wound healing, cancer metastasis and cardiovascular conditions. However, the molecular control of endothelial cell migration is poorly understood. Here, we present a dataset containing siRNA screens that identify known and novel components of signalling pathways regulating migration of lymphatic endothelial cells. These components are compared to signalling in blood vascular endothelial cells. Further, using high-content microscopy, we captured a dataset of images of migrating cells following transfection with a genome-wide siRNA library. These datasets are suitable for the identification and analysis of genes involved in endothelial cell migration and morphology, and for computational approaches to identify signalling networks controlling the migratory response and integration of cell morphology, gene function and cell signaling. This may facilitate identification of protein targets for therapeutically modulating angiogenesis and lymphangiogenesis in the context of human disease.
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