Trial reportMedicine2017
Partial-thickness burn wounds healing by topical treatment: A randomized controlled comparison between silver sulfadiazine and centiderm.
Trial report in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05649332 (Open, Non-comparative, Multicentre, Interventional Post-market Clinical Follow-up), which is not on this map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Open, Non-comparative, Multicentre, Interventional Post-market Clinical Follow-up (PMCF) Study to Evaluate the Performance and Safety of the Medical Device Argogen® (adsorbing Spray Powder for Exudates with Silver Ions) in the Treatment of Pressure Ulcers and Minor (first and Second Degree) Burn Wounds
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Herbal Medicine for the Management of Wounds: A Systematic Review of Clinical Studies.Infectious disorders drug targets · 2025Pooled it
- Interventions for postburn pruritus.The Cochrane database of systematic reviews · 2024Pooled it
- A Systematic Review of the Effect ofInternational journal of environmental research and public health · 2022Pooled it
- Tissue healing efficacy in burn patients treated with 1% silver sulfadiazine versus other treatments: a systematic review and meta-analysis of randomized controlled trials.Anais brasileiros de dermatologiaPooled it
- Nanosilver Dressing in Treating Deep II Degree Burn Wound Infection in Patients with Clinical Studies.Computational and mathematical methods in medicine · 2021Trial
- Moist exposed burn ointment for treating pressure ulcers: A multicenter randomized controlled trial.Medicine · 2017Trial
- Natural phytochemical-based strategies for antibiofilm applications.Chinese medicine · 2025Review
- Chemical burns: pathophysiology and therapeutic protocols-do cervico-facial injuries pose specific challenges?Journal of medicine and life · 2025Article
- Topical Application ofPharmaceutics · 2024Review
- An Overview of Recent Developments in the Management of Burn Injuries.International journal of molecular sciences · 2023Review
- The Potential of Medicinal Plants and Natural Products in the Treatment of Burns and Sunburn-A Review.Pharmaceutics · 2023Review
- Evaluation of Scar Quality after Treatment of Superficial Burns with DressilkJournal of clinical medicine · 2022Article
- Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties.Frontiers in pharmacology · 2022Review
- Therapeutic Efficacy of Great Plantain (International journal of clinical practice · 2022Article
- A clinical comparison of pure knitted silk and a complex synthetic skin substitute for the treatment of partial thickness burns.International wound journal · 2022Article
- Preparation and Safety Evaluation ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats.Antibiotics (Basel, Switzerland) · 2021Article
- Development of a colorlessRSC advances · 2021Article
- Pharmacological Effects ofEvidence-based complementary and alternative medicine : eCAM · 2021Review
- Characterization of a Topically Testable Model of Burn Injury on Human Skin Explants.International journal of molecular sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBurns are common event and associated with a high incidence of death, disability, and high costs. Centella asiatica (L.) is a medicinal herb, commonly growing in humid areas in several tropical countries that improve wound healing. On the basis of previous studies, we compared the efficacy of Centiderm versus silver sulfadiazine (SSD) in partial thickness burning patients.
methodsStudy population comprised burn victims referred to Velayat Burning Hospital at Rasht, Iran. The intervention group received Centiderm and control group SSD cream. Burn wounds were treated once daily at home. All of the wounds were evaluated till complete healing occurred and at the admission, days 3, 7, 14 objective signs; visual acuity score (VAS) and subjective signs were recorded. Re-epithelialization time and complete healing days were recorded. We used random fixed block for randomization. The randomization sequence was created using the computer. Patients and burning specialist physician were blinded.
resultsSeventy-five patients randomized into 2 groups; (40 patients: Centiderm group; 35 patients: SSD group). The mean age of them was 30.67 ± 9.91 years and 19 of them were male (31.7%). Thirty patients in Centiderm and 30 patients in SSD group were analyzed. All of objective and subjective signs and mean of re-epithelialization and complete healing were significantly better in Centiderm group rather than SSD group (P < 0.05). There was no infection in Centiderm group.
conclusionsWe showed that use of Centiderm ointment not only improved the objective and subjective signs in less than 3 days, but also the re-epithelialization and complete healing rather than SSD without any infection in the subjects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.