Evidence map›Paper›PMID 28248831›Full record

ReviewPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2017

Monitoring Severity of Multiple Organ Dysfunction Syndrome: New Technologies.

Katri V Typpo, Hector R Wong, Stacey D Finley, Rodney C Daniels, Andrew J E Seely, Jacques Lacroix

Abstract readReview
In one paragraph

Review in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Recommendations on RBC Transfusion in General Critically Ill Children Based on Hemoglobin and/or Physiologic Thresholds From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2018
    Guideline
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katri V Typpo1Department of Pediatrics and the Steele Children's Research Center, University of Arizona College of Medicine-Tucson, Tucson, AZ. 2Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH. 3Biomedical Engineering Department, Viterbi School of Engineering, University of Southern California, Los Angeles, CA. 4Department of Pediatrics and Communicable Diseases, C.S. Mott Children's Hospital, and Department of Biomedical Engineering, Michigan Center for Integrated Research in Critical Care, University of Michigan, Ann Arbor, MI. 5Division of Thoracic Surgery and Critical Care Medicine, Department of Surgery, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada. 6Division of Pediatric Critical Care Medicine, Department of Pediatrics, Sainte-Justine Hospital, Université de Montréal, Montréal, QC, Canada.
Hector R Wong
Stacey D Finley
Rodney C Daniels
Andrew J E Seely
Jacques Lacroix

Funding

Novel diagnostic and stratification tools for septic shockR01GM108025 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI WONG, HECTOR R. · 2014 to 2017
$2.3M
Stratification of pediatric septic shockR01GM099773 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI WONG, HECTOR R. · 2012 to 2015
$1.5M
Effects of cardiac ICU practice variation on intestinal epithelial barrier function and microbiome diversityK23DK106462 · NIDDK · UNIVERSITY OF ARIZONA · PI TYPPO, KATRI VANAMO · 2016 to 2019
$785k
NIDDK NIH HHS K23 DK106462NIGMS NIH HHS R01 GM099773NIGMS NIH HHS R01 GM108025
6 · The paper itself

Abstract

objectiveTo describe new technologies (biomarkers and tests) used to assess and monitor the severity and progression of multiple organ dysfunction syndrome in children as discussed as part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development MODS Workshop (March 26-27, 2015). DATA SOURCES: Literature review, research data, and expert opinion. STUDY SELECTION: Not applicable. DATA EXTRACTION: Moderated by an experienced expert from the field, investigators developing and assessing new technologies to improve the care and understanding of critical illness presented their research and the relevant literature. DATA SYNTHESIS: Summary of presentations and discussion supported and supplemented by relevant literature.

conclusionsThere are many innovative tools and techniques with the potential application for the assessment and monitoring of severity of multiple organ dysfunction syndrome. If the reliability and added value of these candidate technologies can be established, they hold promise to enhance the understanding, monitoring, and perhaps, treatment of multiple organ dysfunction syndrome in children.

Indexed as

Disease ProgressionSeverity of Illness IndexBiomarkersChildCritical CareCritical IllnessHumansModels, BiologicalMonitoring, PhysiologicMultiple Organ FailurePediatricsRisk AssessmentBiomarkers

Identifiers

PMID28248831
PMCPMC5333164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.