Trial reportMedicine and science in sports and exercise2017
Calcium Supplementation Attenuates Disruptions in Calcium Homeostasis during Exercise.
Trial report in Medicine and science in sports and exercise, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Pooled it
- The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review.Nutrients · 2019Pooled it
- Load carriage aerobic exercise stimulates a transient rise in biochemical markers of bone formation and resorption.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Sclerostin and parathyroid hormone responses to acute whole-body vibration and resistance exercise in young women.Journal of bone and mineral metabolism · 2019Trial
- Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Trial
- Circulating sclerostin is not suppressed following a single bout of exercise in young men.Physiological reports · 2018Trial
- Preparation of Calcium-Chelating Peptides from Squid Skin and Evaluation of Calcium Absorption Capacity in Caco-2 Cell Monolayer Model.Foods (Basel, Switzerland) · 2025Article
- Effect of acute resistance exercise on bone turnover in young adults before and after concurrent resistance and interval training.Physiological reports · 2024Article
- Changes in the concentration of bone turnover markers in men after maximum intensity exercise.PeerJ · 2024Article
- The effect of calcium supplementation on calcium and bone metabolism during load carriage in women: protocol for a randomised controlled crossover trial.BMC musculoskeletal disorders · 2023Article
- Relationship between tinnitus and olfactory dysfunction: audiovisual, olfactory, and medical examinations.Frontiers in public health · 2023Article
- Micronutrient supplement intakes among collegiate and masters athletes: A cross-sectional study.Frontiers in sports and active living · 2023Article
- Dare to jump: The effect of the new high impact activity SuperJump on bone remodeling. A new tool to maintain fitness during COVID-19 home confinement.Biology of sport · 2022Article
- Acute catabolic bone metabolism response to exercise in young and older adults: A narrative review.Experimental gerontology · 2022Review
- Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels.International journal of molecular sciences · 2021Review
- Article
- The Impact of Diet and Physical Activity on Bone Health in Children and Adolescents.Frontiers in endocrinology · 2021Review
- Physical Activity-Dependent Regulation of Parathyroid Hormone and Calcium-Phosphorous Metabolism.International journal of molecular sciences · 2020Review
- Dermal Calcium Loss Is Not the Primary Determinant of Parathyroid Hormone Secretion during Exercise.Medicine and science in sports and exercise · 2019Article
- Bone Biomarker Response to Walking under Different Thermal Conditions in Older Adults.Medicine and science in sports and exercise · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
An exercise-induced decrease in serum ionized calcium (iCa) is thought to trigger an increase in parathyroid hormone (PTH), which can stimulate bone resorption. PURPOSE: The purpose of this study was to determine whether taking a chewable calcium (Ca) supplement 30 min before exercise mitigates disruptions in Ca homeostasis and bone resorption in competitive male cyclists.
methodsFifty-one men (18 to 45 yr old) were randomized to take either 1000 mg Ca (CA) or placebo (PL) 30 min before a simulated 35-km cycling time trial. Serum iCa and PTH were measured before and immediately after exercise and a marker of bone resorption (C-terminal telopeptide of type I collagen) was measured before and 30 min after exercise.
resultsSerum iCa decreased in both groups from before to after exercise (mean ± SD, CA = 4.89 ± 0.16 to 4.76 ± 0.11 mg·dL, PL = 4.92 ± 0.15 to 4.66 ± 0.22 mg·dL, both P ≤ 0.01); the decrease was greater (P = 0.03) in the PL group. There was a nonsignificant (P = 0.07) attenuation of the increase in PTH by Ca supplementation (CA = 30.9 ± 13.0 to 79.7 ± 42.6 pg·mL, PL = 37.1 ± 14.8 to 111.5 ± 49.4 pg·mL, both P ≤ 0.01), but no effect of Ca on the change in C-terminal telopeptide of type I collagen, which increased in both groups (CA = 0.35 ± 0.17 to 0.50 ± 0.21 ng·mL, PL = 0.36 ± 0.13 to 0.54 ± 0.22 ng·mL, both P ≤ 0.01).
conclusionIt is possible that ingesting Ca only 30 min before exercise was not a sufficient time interval to optimize gut Ca availability during exercise. Further studies will be needed to determine whether adequate Ca supplementation before and/or during exercise can fully mitigate the exercise-induced decrease in serum iCa and increases in PTH and bone resorption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.