ArticleEnvironmental health perspectives2017
Health Risk Assessment of Dietary Cadmium Intake: Do Current Guidelines Indicate How Much is Safe?
Article in Environmental health perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
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Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 197 citations in OpenAlex.
- Interventions to reduce cadmium exposure in low- and middle-income countries during pregnancy and childhood: A systematic review.Journal of global health · 2022Pooled it
- Impact of environmental heavy metal exposure on cardiovascular disease mortality.American journal of preventive cardiology · 2026Article
- Colorimetric Sensing of Cd(II) Using 4-Fluorobenzohydrazide-Stabilized Silver Nanoparticles and Evaluation of Photodegradation and Antibacterial Properties.Applied biochemistry and biotechnology · 2026Article
- Cadmium toxicity to the human gut microbiome varies depending on composition.Applied and environmental microbiology · 2026Article
- Residual metal soil contamination and associated health risks in a native American community within a remediated Superfund site in New Jersey, USA.Environmental science and pollution research international · 2026Article
- Health risk assessment and ionomic profiling under cadmium, lead, zinc, and manganese stress in Amaranthus cruentus.BMC plant biology · 2026Article
- Distribution of Toxic and Essential Elements in Autopsy Organs of Subjects Living in South-Eastern Poland.International journal of molecular sciences · 2026Article
- Cadmium-Induced Testicular and Spermatogonial Damage Ameliorated by Bryonia laciniosa Linn. Seeds in Wistar Rats: An Animal Study.Biological trace element research · 2026Article
- Dietary risk analysis of heavy metal and metalloid pollution in rice: case study of Nanning City in China.Frontiers in public health · 2026Article
- Single-Cell Multiome Impact of Prenatal Heavy Metal Exposure on Early Airway Development.American journal of respiratory cell and molecular biology · 2026Article
- Exposure to Heavy Metals Arsenic, Cadmium and Lead Exacerbates Carcinogenic and Noncarcinogenic Health Risks Among Diabetic and Hypertensive Patients.Journal of toxicology · 2026Article
- Cadmium toxicity to the human gut microbiome varies depending on composition.bioRxiv : the preprint server for biology · 2025Article
- Health risk assessment of toxic elements and nitrate in tuberous vegetables: carcinogenic and non-carcinogenic perspectives, monte carlo simulation, and sensitivity analysis.Scientific reports · 2025Article
- A Review of Reducing Cadmium Pollution in the Rice-Soil System in China.Foods (Basel, Switzerland) · 2025Review
- Melatonin may protect the gastrointestinal system from cadmium chloride toxicity during pregnancy.Toxicology research · 2025Article
- Polyphenolic Composition, Antioxidant Activity, and Cytotoxic Effect of Male Floral Buds from ThreeMolecules (Basel, Switzerland) · 2025Article
- Mitigating Cadmium Toxicity: Role of Caffeine in the Reduction of Oxidative Stress.Open veterinary journal · 2025Article
- Melatonin prevents histopathologies stem from cadmium chloride in pregnant mice lungs.Journal of molecular histology · 2024Article
- Blocking SIG1R Along with Low Cadmium Exposure Display Anti-cancer Qualities in Both MCF7 and MDA-MB-231 Cells.Biological trace element research · 2024Article
- Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCadmium (Cd), a food-chain contaminant, is a significant health hazard. The kidney is one of the primary sites of injury after chronic Cd exposure. Kidney-based risk assessment establishes the urinary Cd threshold at 5.24 μg/g creatinine, and tolerable dietary intake of Cd at 62 μg/day per 70-kg person. However, cohort studies show that dietary Cd intake below a threshold limit and that tolerable levels may increase the risk of death from cancer, cardiovascular disease, and Alzheimer's disease.
objectiveWe evaluated if the current tolerable dietary Cd intake guideline and urinary Cd threshold limit provide sufficient health protection. DISCUSSION: Staple foods constitute 40-60% of total dietary Cd intake by average consumers. Diets high in shellfish, crustaceans, mollusks, spinach, and offal add to dietary Cd sources. Modeling studies predict the current tolerable dietary intake corresponding to urinary Cd of 0.70-1.85 μg/g creatinine in men and 0.95-3.07 μg/g creatinine in women. Urinary Cd levels of < 1 μg/g creatinine were associated with progressive kidney dysfunction and peripheral vascular disease. A urinary Cd of 0.37 μg/g creatinine was associated with breast cancer, whereas dietary Cd of 16-31.5 μg/day was associated with 25-94% increase in risk of estrogen receptor-positive breast cancer.
conclusionModeling shows that dietary intake levels for Cd exceed the levels associated with kidney damage and many other adverse outcomes. Thus, the threshold level of urinary Cd should be re-evaluated. A more restrictive dietary intake guideline would afford enhanced health protection from this pervasive toxic metal. Citation: Satarug S, Vesey DA, Gobe GC. 2017. Health risk assessment of dietary cadmium intake: do current guidelines indicate how much is safe? Environ Health Perspect 125:284-288; http://dx.doi.org/10.1289/EHP108.
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